连续修整切除术有利于预后，是治疗口腔舌癌的一种新手术策略。

Modified in-continuity resection is advantageous for prognosis and as a new surgical strategy for management of oral tongue cancer.

机构信息

Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 May;129(5):453-460. doi: 10.1016/j.oooo.2019.09.016. Epub 2019 Oct 14.

DOI:10.1016/j.oooo.2019.09.016

PMID:32102766

Abstract

OBJECTIVE

The aim of this study was to explore the application value of modified in-continuity resection compared with traditional in-continuity resection and discontinuous resection for patients with cT2 N0 M0 oral tongue squamous cell carcinoma.

STUDY DESIGN

This was a retrospective cohort study. The predictor was surgical management. The main outcome assessment parameters were the 5-year intervening regional (submandibular area and floor of mouth) recurrence rate and the 5-year disease-specific survival rate. Descriptive and bivariate statistics were computed, and the P value was .05.

RESULTS

We reviewed 406 patients: 212 in the discontinuous resection group, 101 in the in-continuity resection group, and 93 in the modified in-continuity resection group. Kaplan-Meier analysis showed that modified in-continuity resection was better than discontinuous resection with regard to both 5-year intervening regional recurrence (6.3% vs 18.8%; P = .004) and 5-year disease-specific survival (88.6% vs 75.1%; P = .003). Additionally, modified in-continuity resection had a lower postoperative complication rate compared with in-continuity resection (3.8% vs 13.2%; P = .044).

CONCLUSIONS

The modified in-continuity resection is valuable for application in clinical practice for cT2 N0 M0 oral tongue squamous cell carcinoma.

摘要

目的

本研究旨在探讨改良连续切除术与传统连续切除术和间断切除术相比，在 cT2N0M0 口腔舌鳞癌患者中的应用价值。

研究设计

这是一项回顾性队列研究。预测因子为手术治疗。主要观察指标为 5 年局部（颌下区和口底）复发率和 5 年疾病特异性生存率。计算描述性和双变量统计数据，P 值为.05。

结果

我们回顾了 406 例患者：间断切除术组 212 例，连续切除术组 101 例，改良连续切除术组 93 例。Kaplan-Meier 分析显示，改良连续切除术在 5 年局部复发（6.3%比 18.8%；P=.004）和 5 年疾病特异性生存率（88.6%比 75.1%；P=.003）方面均优于间断切除术。此外，改良连续切除术的术后并发症发生率低于连续切除术（3.8%比 13.2%；P=.044）。