Faculty of Engineering, Department of Mechanics, Imam Khomeini International University, Qazvin, P.O. Box 34149-16818, Iran.
Sci Rep. 2020 Feb 26;10(1):3439. doi: 10.1038/s41598-020-60105-3.
The DNA molecule is the most evolved and most complex molecule created by nature. The primary role of DNA in medicine is long-term storage of genetic information. Genetic modifying is one of the most critical challenges that scientists face. On the other hand, it is said that under the influence of acoustic, electromagnetic, and scalar waves, the genetic code of DNA can be read or rewritten. In this article, the most accurate and comprehensive dynamic model will be presented for DNA. Each of the two strands is modeled with an out of plane curved beam and then by doubling this two strands with springs, consider the hydrogen bond strength between this two strands. Beams are traditionally descriptions of mechanical engineering structural elements or building. However, any structure such as automotive automobile frames, aircraft components, machine frames, and other mechanical or structural systems contain beam structures that are designed to carry lateral loads are analyzed similarly. Also, in this model, the mass of the nucleobases in the DNA structure, the effects of the fluid surrounding the DNA (nucleoplasm) and the effects of temperature changes are also considered. Finally, by deriving governing equations from Hamilton's principle method and solving these equations with the generalized differential quadrature method (GDQM), the frequency and mode shape of the DNA is obtained for the first time. In the end, validation of the obtained results from solving the governing equations of mathematical model compared to the obtained results from the COMSOL software is confirmed. By the help of these results, a conceptual idea for controlling cancer with using the DNA resonance frequency is presented. This idea will be presented to stop the cancerous cell's protein synthesis and modifying DNA sequence and genetic manipulation of the cell. On the other hand, by the presented DNA model and by obtaining DNA frequency, experimental studies of the effects of waves on DNA such as phantom effect or DNA teleportation can also be studied scientifically and precisely.
DNA 分子是自然界创造的最进化和最复杂的分子。DNA 在医学中的主要作用是长期存储遗传信息。基因修饰是科学家面临的最关键挑战之一。另一方面，据说在声波、电磁场和标量波的影响下，DNA 的遗传密码可以被读取或重写。在本文中，将呈现最准确和全面的 DNA 动力学模型。每一条链都用一个平面外弯曲梁建模，然后通过用弹簧加倍这两条链，考虑这两条链之间的氢键强度。梁传统上是机械工程结构元件或建筑物的描述。然而，任何结构，如汽车车架、飞机部件、机器框架和其他机械或结构系统，都包含承受横向载荷的梁结构，这些结构也可以类似地进行分析。此外，在这个模型中，还考虑了 DNA 结构中核碱基的质量、DNA 周围流体（核质）的影响以及温度变化的影响。最后，通过从哈密顿原理方法推导出控制方程，并使用广义微分求积法（GDQM）求解这些方程，首次获得了 DNA 的频率和振型。最后，通过将数学模型控制方程的求解结果与 COMSOL 软件的求解结果进行比较，验证了所得到的结果的正确性。通过这些结果，提出了一种利用 DNA 共振频率控制癌症的概念性想法。这个想法将用于阻止癌细胞的蛋白质合成、修改 DNA 序列和对细胞进行基因操作。另一方面，通过呈现的 DNA 模型，并获得 DNA 频率，可以对波对 DNA 的影响进行科学和精确的实验研究，如幻波效应或 DNA 瞬移。
