Department of Radiophysics and Nanothechnology, Physics Faculty, Kuban State University, 350040 Krasnodar, Russia.
Laboratory of Problems of Stable Isotope Spreading in Living Systems, Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia.
Int J Mol Sci. 2021 Jul 23;22(15):7873. doi: 10.3390/ijms22157873.
The sensitivity of DNA to electromagnetic radiation in different ranges differs depending on various factors. The aim of this study was to examine the molecular dynamics of DNA under the influence of external periodic influences with different frequencies. In the present paper, within the framework of a mechanical model without simplifications, we investigated the effect of various frequencies of external periodic action in the range from 10 s to 10 s on the dynamics of a DNA molecule. It was shown that under the influence of an external periodic force, a DNA molecule can perform oscillatory movements with a specific frequency characteristic of this molecule, which differs from the frequency of the external influence . It was found that the frequency of such specific vibrations of a DNA molecule depends on the sequence of nucleotides. Using the developed mathematical model describing the rotational motion of the nitrogenous bases around the sugar-phosphate chain, it is possible to calculate the frequency and amplitude of the oscillations of an individual DNA area. Such calculations can find application in the field of molecular nanotechnology.
不同范围内的 DNA 对电磁辐射的敏感性取决于各种因素。本研究的目的是研究在不同频率的外部周期性影响下 DNA 的分子动力学。在本文中，我们在没有简化的力学模型框架内，研究了从 10 s 到 10 s 范围内不同频率的外部周期性作用对 DNA 分子动力学的影响。结果表明，在外部周期性力的作用下，DNA 分子可以进行具有特定频率的振荡运动，该频率特征与外部影响的频率不同。结果表明，DNA 分子的这种特定振动的频率取决于核苷酸的序列。使用描述含氮碱基围绕糖-磷酸链旋转运动的开发数学模型，可以计算单个 DNA 区域的振动频率和幅度。这种计算在分子纳米技术领域有应用的可能。
