Ito K, Izumi K, Takagi H, Tamaya T, Hayasaki M
Department of Obstetrics and Gynecology, School of Medicine, Gifu University.
Jpn J Antibiot. 1988 Nov;41(11):1778-85.
To evaluate the efficacy of imipenem/cilastatin sodium (IPM/CS) in the field of obstetrics and gynecology, fundamental (measurement of IPM/CS concentrations in mothers' milk) and clinical studies were performed. Concentrations of IPM/CS in mothers' milk were measured every 1 hour up to 6 hours after a 30-minute drip infusion of 500 mg/500 mg of IPM/CS. IPM/CS was distributed similarly to other cephalosporins. In the clinical study, a 500 mg/500 mg dose of IPM/CS was administered to 5 patients with puerperal intrauterine infections and to 3 patients with urinary tract infections by a 30-minute drip infusion b.i.d. or t.i.d. Good responses were observed in all 8 patients, though the infections were mild or moderate. From these results, IPM/CS appeared to be a useful drug for the treatment of perinatal infections.
为评估亚胺培南/西司他丁钠（IPM/CS）在妇产科领域的疗效，开展了基础研究（测定母乳中亚胺培南/西司他丁钠的浓度）和临床研究。在静脉滴注500mg/500mg亚胺培南/西司他丁钠30分钟后，每1小时测定一次母乳中亚胺培南/西司他丁钠的浓度，持续6小时。亚胺培南/西司他丁钠的分布与其他头孢菌素相似。在临床研究中，对5例产褥期宫内感染患者和3例尿路感染患者，采用静脉滴注30分钟，每日2次或3次的方式给予500mg/500mg剂量的亚胺培南/西司他丁钠。尽管感染为轻度或中度，但所有8例患者均观察到良好疗效。根据这些结果，亚胺培南/西司他丁钠似乎是治疗围产期感染的一种有用药物。
