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商业化直接面向消费者的家用 DNA 检测试剂盒时代的生育保健:值得思考的问题。

Fertility care in the era of commercial direct-to-consumer home DNA kits: issues to ponder.

机构信息

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill University, Montréal, Quebec, H3A 0G4, Canada.

MUHC Reproductive Centre, McGill University, Montréal, Quebec, H2L 4S8, Canada.

出版信息

J Assist Reprod Genet. 2020 Mar;37(3):689-692. doi: 10.1007/s10815-020-01711-y. Epub 2020 Feb 26.

DOI:10.1007/s10815-020-01711-y
PMID:32103399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7125273/
Abstract

Recently, we have witnessed a shift in the nature of genetic testing. What was once solely in the hands of the scientific community is now easily accessible to anyone. Commercial companies such as Veritas Genetics, Ancestry, and 23andMe offer cheap direct-to-consumer home DNA kits that are branded as a "health and ancestry service." These tests are gaining in popularity, and it is estimated that since their marketing, over 30 million people worldwide have provided their DNA samples. The implications of this new genetic era are diverse, ranging from the individuals personal health assessment, to family genealogy and ancestry, and the complexity of establishing an enormous population-based genetic database. Unique implications of commercial DNA tests on fertility patients and heath care providers, such as in the case of gamete donation, are important to acknowledge and have implications for reproductive care.

摘要

最近,我们见证了基因检测性质的转变。曾经仅掌握在科学界手中的技术,现在任何人都可以轻松获取。Veritas Genetics、Ancestry 和 23andMe 等商业公司提供廉价的直接面向消费者的家用 DNA 试剂盒,这些试剂盒被标榜为“健康和祖源服务”。这些测试越来越受欢迎,据估计,自推出以来,全世界已有超过 3000 万人提供了他们的 DNA 样本。这个新的基因时代的影响是多方面的,从个人的健康评估,到家庭基因alogy 和祖源,再到建立庞大的基于人群的基因数据库的复杂性。商业 DNA 测试对生育患者和医疗保健提供者的独特影响,例如配子捐赠,是需要承认的,并且对生殖护理有影响。

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本文引用的文献

1
Sperm donor anonymity: a concept rendered obsolete by modern technology.精子捐献者匿名制:一个被现代技术淘汰的概念。
Fertil Steril. 2018 Feb;109(2):230-231. doi: 10.1016/j.fertnstert.2017.12.011. Epub 2018 Jan 11.
2
Committee Opinion No. 693: Counseling About Genetic Testing and Communication of Genetic Test Results.第693号委员会意见:基因检测咨询与基因检测结果的传达
Obstet Gynecol. 2017 Apr;129(4):e96-e101. doi: 10.1097/AOG.0000000000002020.
3
Current regulatory arrangements for assisted conception treatment in European countries.欧洲国家目前关于辅助生殖治疗的监管安排。
Eur J Obstet Gynecol Reprod Biol. 2016 Dec;207:211-213. doi: 10.1016/j.ejogrb.2016.10.002. Epub 2016 Oct 20.
4
Informing offspring of their conception by gamete or embryo donation: a committee opinion.告知配子或胚胎捐赠受孕后代:委员会意见。
Fertil Steril. 2013 Jul;100(1):45-9. doi: 10.1016/j.fertnstert.2013.02.028. Epub 2013 Mar 7.
5
Revised guidelines for human embryology and andrology laboratories.人类胚胎学与男科学实验室修订指南。
Fertil Steril. 2008 Nov;90(5 Suppl):S45-59. doi: 10.1016/j.fertnstert.2008.08.099.