Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Br J Haematol. 2020 Jun;189(5):908-912. doi: 10.1111/bjh.16447. Epub 2020 Feb 27.
To determine whether inflammatory markers, derived neutrophil-to-lymphocyte ratio (dNLR), haemoglobin/platelet ratio (HPR) or platelet/lymphocyte ratio (PLR) are predictive for prognosis in angioimmunoblastic T-cell lymphoma (AITL), we derived dNLR, HPR and PLR values for 110 AITL patients and appropriate cut-off point values to define overall survival (OS) and progression-free survival (PFS). dNLR ≥ 2·2, HPR ≥ 0·4 or PLR < 100 were significant factors for shorter OS and PFS. On univariate analysis, these three parameters were significantly associated with worse OS and PFS. On multivariate analysis, only dNLR remained a significant, independent prognostic factor for both OS and PFS.
为了确定炎症标志物、衍生中性粒细胞与淋巴细胞比值（dNLR）、血红蛋白/血小板比值（HPR）或血小板/淋巴细胞比值（PLR）是否对血管免疫母细胞性 T 细胞淋巴瘤（AITL）的预后有预测价值，我们为 110 例 AITL 患者推导了 dNLR、HPR 和 PLR 值，并确定了合适的截断值来定义总生存（OS）和无进展生存（PFS）。dNLR≥2.2、HPR≥0.4 或 PLR＜100 是 OS 和 PFS 较短的显著因素。在单因素分析中，这三个参数与较差的 OS 和 PFS 显著相关。在多因素分析中，只有 dNLR 仍然是 OS 和 PFS 的显著独立预后因素。
