Shen Qian-Qing, Gao Jie, Tao Huan, Wang Shuo-Ting, Wang Fu-Jue, Chen Ying-Ying, Zhang Xue, Jia Yong-Qian
Department of Hematology, West China Hospital, Sichuan University Chengdu 610041, Sichuan, China.
Am J Blood Res. 2021 Feb 15;11(1):100-110. eCollection 2021.
The inflammatory and immune cells have an important impact on Hodgkin lymphoma (HL). The derived neutrophil-lymphocyte ratio (dNLR) has been confirmed to have a similar prognostic value as the neutrophil-lymphocyte ratio (NLR) in many kinds of tumors, but it has not been explored as a prognostic marker for Hodgkin lymphoma patients.
The aim of the study is to evaluate the prognostic value of dNLR and NLR in HL.
This retrospective study included 213 newly diagnosed HL patients from 2008 to 2019. Then, the prognostic significance of dNLR and NLR in these patients was evaluated. Meanwhile, subgroup analyses based on the Ann Arbor stage and histotype were also carried out. Finally, propensity score matching was used to reduce selection bias.
Patients with dNLR ≥ 2.1 showed shorter overall survival (OS) (P = 0.006). Also, patients with NLR ≥ 3.0 showed worse OS (P = 0.005) and progression-free survival (PFS) (P = 0.031). These results were also found in patients with early-stage and mixed cellularity subtype HL. Besides, high dNLR represented an independent prognostic marker for OS and high NLR remained an independent prognostic factor for OS and PFS on multivariable analysis.
Elevated dNLR and NLR were related to worse survival in HL patients. For the first time, the dNLR has shown the potential to be a new prognostic factor for patients with HL.
炎症和免疫细胞对霍奇金淋巴瘤（HL）具有重要影响。衍生中性粒细胞与淋巴细胞比值（dNLR）已被证实在多种肿瘤中具有与中性粒细胞与淋巴细胞比值（NLR）相似的预后价值，但尚未作为霍奇金淋巴瘤患者的预后标志物进行探索。
本研究旨在评估dNLR和NLR在HL中的预后价值。
这项回顾性研究纳入了2008年至2019年新诊断的213例HL患者。然后，评估dNLR和NLR在这些患者中的预后意义。同时，还基于Ann Arbor分期和组织学类型进行了亚组分析。最后，采用倾向评分匹配来减少选择偏倚。
dNLR≥2.1的患者总生存期（OS）较短（P = 0.006）。此外，NLR≥3.0的患者OS较差（P = 0.005），无进展生存期（PFS）也较差（P = 0.031）。在早期和混合细胞型亚型HL患者中也发现了这些结果。此外，多变量分析显示，高dNLR是OS的独立预后标志物，高NLR仍然是OS和PFS的独立预后因素。
dNLR和NLR升高与HL患者较差的生存率相关。dNLR首次显示出成为HL患者新预后因素的潜力。
