Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gang-Dong, School of Medicine, Kyung Hee University, Seoul, Korea.
Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
J Korean Med Sci. 2020 Mar 2;35(8):e58. doi: 10.3346/jkms.2020.35.e58.
Although the association of hyperuricemia with an increased risk of mortality has been demonstrated in the context of acute exacerbation of chronic obstructive pulmonary disease (COPD), the long-term outcomes of hyperuricemia have not been studied in the case of stable COPD.
We retrospectively analyzed baseline data of 240 men with stable COPD enrolled in the Korea Obstructive Lung Disease cohort. We evaluated associations between serum uric acid levels and clinical parameters, risk factors for all-cause mortality, and acute exacerbation of COPD.
The mean age of subjects was 66.4 ± 7.7 years, and the median follow-up time was 5.9 years. We identified no significant difference in terms of lung function or laboratory findings between patients with hyperuricemia and those without. Serum uric acid level was negatively associated with systemic inflammation indicated by neutrophil-lymphocyte ratio ( = -0.211, = 0.001). Univariate Cox regression analysis revealed hyperuricemia to not be associated with an increased risk of all-cause mortality in men with stable COPD (hazard ratio [HR], 0.580; 95% confidence interval [CI], 0.250-1.370; = 0.213). In the multivariate Cox regression model, hyperuricemia was not an independent predictor of acute exacerbation (HR, 1.383; 95% CI, 0.977-1.959; = 0.068).
Among men with stable COPD, hyperuricemia is not an independent predictor of all-cause mortality or future acute exacerbation of COPD. These results differ from those of previous studies on patients with acute exacerbation of COPD.
尽管高尿酸血症与慢性阻塞性肺疾病（COPD）急性加重的死亡率增加有关，但在 COPD 稳定期，高尿酸血症的长期预后尚未得到研究。
我们回顾性分析了韩国阻塞性肺疾病队列中 240 名稳定期 COPD 男性患者的基线数据。我们评估了血清尿酸水平与临床参数、全因死亡率和 COPD 急性加重风险因素之间的关系。
受试者的平均年龄为 66.4 ± 7.7 岁，中位随访时间为 5.9 年。我们发现高尿酸血症患者和无高尿酸血症患者在肺功能或实验室检查方面没有显著差异。血清尿酸水平与中性粒细胞-淋巴细胞比值（ = -0.211， = 0.001）所表示的全身炎症呈负相关。单因素 Cox 回归分析显示，高尿酸血症与稳定期 COPD 男性的全因死亡率增加无关（危险比[HR]，0.580；95%置信区间[CI]，0.250-1.370； = 0.213）。在多因素 Cox 回归模型中，高尿酸血症不是急性加重的独立预测因子（HR，1.383；95%CI，0.977-1.959； = 0.068）。
在稳定期 COPD 男性中，高尿酸血症不是全因死亡率或未来 COPD 急性加重的独立预测因子。这些结果与以前关于急性加重期 COPD 患者的研究结果不同。
