MOG 自身抗体相关的 MRI 阴性脊髓炎的频率和特征。
Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies.
机构信息
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Division of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, MN, USA.
出版信息
Mult Scler. 2021 Feb;27(2):303-308. doi: 10.1177/1352458520907900. Epub 2020 Feb 27.
Abstract
BACKGROUND
Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty.
OBJECTIVE AND METHODS
We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000-2019).
RESULTS
The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5-8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte's phenomenon). Myelitis lesions became overt at follow-up MRI in three patients.
CONCLUSIONS
A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.
摘要
背景
脊髓炎伴阴性脊髓 MRI 可能导致诊断不确定。
目的和方法
我们回顾性调查了 Mayo 诊所 2000 年至 2019 年间患有髓鞘少突胶质细胞糖蛋白（MOG）-IgG 相关脊髓炎的患者中（发病后<6 周）阴性脊髓 MRI 的频率。
结果
尽管存在严重的急性残疾（中位 EDSS，7（范围，4.5-8）），但 73 例患者中有 7 例（10%）的初始脊髓 MRI 为阴性；脊髓炎症状/体征常见（截瘫、神经性膀胱、感觉水平、Lhermitte 现象）。在三名患者中，随访 MRI 时出现明显的脊髓炎病变。
结论
对于急性/亚急性脊髓炎患者，阴性脊髓 MRI 不应阻止 MOG-IgG 检测。
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