3,5-双（三氟甲基）苯基三氟甲磺酸盐（BFPAT）作为一种新型有机催化剂用于高效合成2,3-二氢喹唑啉-4（1H）-酮衍生物。
3,5-Bis(trifluoromethyl) Phenylammonium triflate(BFPAT) as a Novel Organocatalyst for the Efficient Synthesis of 2,3-dihydroquinazolin-4(1H)-one Derivatives.
作者信息
Alipour Mandana, Hossaini Zinatossadat, Khaksar Samad, Rostami-Charati Faramarz
机构信息
Department of Chemistry, Islamic Azad University, Qaemshahr Branch, Qaemshahr, Iran.
Department of Chemistry, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran.
出版信息
Curr Org Synth. 2020;17(1):40-45. doi: 10.2174/1570179417666191218115126.
AIMS AND OBJECTIVES
A one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives by threecomponent cyclo-condensation of isatoic anhydride, aldehydes and amine or ammonium acetate has been developed using 3,5-Bis(trifluoromethyl) phenylammonium triflate (BFPAT) as a new organocatalyst.
MATERIALS AND METHODS
All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points.
RESULTS
A wide variety of structurally different aldehydes reacted easily and rapidly to result in the relating 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yield.
CONCLUSION
We have demonstrated an extremely effective and new process for synthesizing 2,3- dihydroquinazolin-4(1H)-ones employing BFPAT as a novel organocatalyst in one-pot fashion.
目的与目标
以3,5-双（三氟甲基）苯基三氟甲磺酸铵（BFPAT）作为新型有机催化剂，开发了一种通过邻苯二甲酸酐、醛与胺或乙酸铵的三组分环缩合反应一锅法合成2,3-二氢喹唑啉-4(1H)-酮衍生物的方法。
材料与方法
所有得到的产物均为已知化合物，并通过红外光谱（IR）、核磁共振氢谱（1HNMR）、核磁共振碳谱（13CNMR）和熔点进行鉴定。
结果
多种结构不同的醛能轻松快速地反应，以良好至优异的产率得到相应的2,3-二氢喹唑啉-4(1H)-酮。
结论
我们展示了一种极其有效且新颖的方法，即采用BFPAT作为新型有机催化剂，以一锅法合成2,3-二氢喹唑啉-4(1H)-酮。
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