Hosseinzadeh Rahman, Zarei Shiva, Valipour Zohreh, Maleki Behrooz
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Heliyon. 2024 Sep 17;10(19):e37170. doi: 10.1016/j.heliyon.2024.e37170. eCollection 2024 Oct 15.
Efficient and green protocols were reported to synthesize 2,3-dihydroquinazolin-4(1H)-one derivatives in natural deep eutectic solvent (NADES). NADES was prepared from ascorbic acid (AA) and choline chloride (ChCl) with reduced or null toxicity, biocompatibility, and low cost. The ChCl/AA NADES was successfully used in the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives via the condensation reaction of aldehydes with 2-aminobenzamide and the three-component reactions of aldehydes, isatoic anhydrides and ammonium salts under solvent-free conditions. The scope of this method was evaluated by employing various aromatic, heterocyclic, and aliphatic aldehydes. The desired products were achieved in 85-97 % yield in a short reaction time. Also, the deep eutectic solvent ChCl/AA showed good recyclability and reusability.
据报道，在天然低共熔溶剂（NADES）中可通过高效且绿色的方法合成2,3-二氢喹唑啉-4(1H)-酮衍生物。NADES由抗坏血酸（AA）和氯化胆碱（ChCl）制备而成，具有低毒性或无毒性、生物相容性且成本低廉。ChCl/AA NADES通过醛与2-氨基苯甲酰胺的缩合反应以及醛、异邻苯二甲酸酐和铵盐在无溶剂条件下的三组分反应，成功用于合成2,3-二氢喹唑啉-4(1H)-酮衍生物。通过使用各种芳香醛、杂环醛和脂肪醛对该方法的适用范围进行了评估。在短反应时间内，所需产物的产率达到85 - 97%。此外，低共熔溶剂ChCl/AA显示出良好的可回收性和可重复使用性。
