Future Medicine Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Deajeon, 305-811, Republic of Korea.
BMC Endocr Disord. 2020 Feb 27;20(1):29. doi: 10.1186/s12902-020-0510-0.
The metabolic syndrome (MetS) has shown strong associations with the hypertriglyceridemic waist (HW) phenotype. The best anthropometric indicator of MetS remains controversial. Furthermore, no studies have investigated alternative indices that could replace waist circumference in the HW phenotype. The objectives of this study were to find the best indicator of MetS among anthropometric indices and to examine the predictive power of phenotypes consisting of triglyceride levels with anthropometric indices.
A total of 12,025 subjects participated in this retrospective cross-sectional study. All subjects were recruited between November 2016 and August 2007 from hospitals in 28 urban and rural regions in South Korea. The data analyzed in this study were obtained from the Korean Health and Genome Epidemiology Study database and the Korea Institute of Oriental Medicine.
The proportion of patients with MetS ranged from 9 to 57% according to age and gender groups. Waist circumference (WC) was best indicator of MetS in men of all age groups. However, in women aged 40-49 years, the waist-to-height ratio (WHtR) was the best indicator of MetS. Rib circumference and chest circumference were the strongest indicators in women aged 50-59 years and 70-79 years, respectively. The combination of WC and triglyceride (TG) was the best indicator of MetS in men and women overall. However, interestingly, the best indicator was TG + WHtR in women aged 40-49 years and TG + forehead-to-waist ratio in women aged 70-79 years.
The best indicator of MetS in terms of individual anthropometric indices and the various phenotypes combining a single anthropometric index with TG may differ subtly according to age group in women, but not in men. Our findings provide insight into a simple and inexpensive method that could be used to identify MetS in initial health screening efforts in epidemiology and public health.
代谢综合征（MetS）与高甘油三酯性腰围（HW）表型有很强的相关性。用于诊断 MetS 的最佳人体测量学指标仍存在争议。此外，尚无研究探讨替代腰围指标，以用于 HW 表型。本研究旨在寻找人体测量学指标中诊断 MetS 的最佳指标，并检验包含甘油三酯水平和人体测量学指标的表型的预测能力。
本回顾性横断面研究共纳入 12025 名受试者。所有受试者均于 2016 年 11 月至 2007 年 8 月间，从韩国 28 个城乡地区的医院招募。本研究分析的数据来自韩国健康与基因组流行病学研究数据库和韩国东医研究院。
按年龄和性别分组，MetS 患者的比例在 9%至 57%之间。腰围（WC）是所有年龄段男性 MetS 的最佳指标。然而，在 40-49 岁女性中，腰高比（WHtR）是 MetS 的最佳指标。肋围和胸围是 50-59 岁和 70-79 岁女性中最强的指标。WC 和甘油三酯（TG）联合是男女整体 MetS 的最佳指标。但有趣的是，40-49 岁女性的最佳指标是 TG+WHtR，70-79 岁女性的最佳指标是 TG+额腰比。
就个体人体测量学指标而言，以及将单个人体测量学指标与 TG 结合的各种表型，最佳指标在女性中可能会根据年龄组略有不同，但在男性中没有差异。本研究结果为流行病学和公共卫生领域初始健康筛查中识别 MetS 提供了一种简单、廉价的方法。
