结膜下注射环孢素治疗大鼠急性过敏性结膜炎的有效性
Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model.
作者信息
Awara Amr, Atiba Ayman, Helal Duaa, Elbedewy Hazem
机构信息
Ophthalmology Department, Tanta University, Tanta, Egypt.
Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
出版信息
Clin Ophthalmol. 2020 Feb 13;14:431-435. doi: 10.2147/OPTH.S244287. eCollection 2020.
BACKGROUND
Eye allergy is widely spread worldwide. The treatment includes topical anti-histamines, steroids and non-steroidal drugs. Steroids are the first choice by many ophthalmologists, but unfortunately they may cause serious side effects. Cyclosporine A (CsA) is an immunomodulator drug that can improve eye allergy and reduce the need for steroids; however, topical preparation of CsA is difficult because of the lipophilic nature of the drug.
METHODS
An experimental study included 16 rats with induced allergy were divided into 2 groups. Group 1: allergic non-treated (6 rats), and Group 2: allergic treated with 0.5 mL subconjunctival CsA 1% (10 rats). Half of each group was sacrificed at 24 hrs and the other half at 1 week. Conjunctival hyperemia and eosinophilic cell count were assessed at each time.
RESULTS
Group 2 (CsA treated) showed significantly lower hyperemia score and eosinophilic count at both 24 hrs and 1 week. No ocular complications were noted.
CONCLUSION
Subconjunctival CsA was safe and effective in treating ocular allergy through improving conjunctival hyperemia and reducing eosinophilic cell count with no significant ocular side effects.
背景
眼部过敏在全球广泛传播。治疗方法包括局部使用抗组胺药、类固醇和非甾体类药物。类固醇是许多眼科医生的首选药物，但不幸的是，它们可能会引起严重的副作用。环孢素A（CsA）是一种免疫调节剂药物，可改善眼部过敏并减少对类固醇的需求；然而，由于该药物的亲脂性，CsA的局部制剂制备困难。
方法
一项实验研究将16只诱导过敏的大鼠分为2组。第1组：未治疗的过敏大鼠（6只），第2组：用0.5 mL结膜下注射1% CsA治疗的过敏大鼠（10只）。每组一半在24小时处死，另一半在1周时处死。每次均评估结膜充血和嗜酸性粒细胞计数。
结果
第2组（CsA治疗组）在24小时和1周时的充血评分和嗜酸性粒细胞计数均显著降低。未观察到眼部并发症。
结论
结膜下注射CsA通过改善结膜充血和减少嗜酸性粒细胞计数来治疗眼部过敏是安全有效的，且无明显的眼部副作用。
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