一项关于影响中国卵巢癌患者生活质量的心理因素的研究。
A Study on the Psychological Factors Affecting the Quality of Life Among Ovarian Cancer Patients in China.
作者信息
Gu Zhi-Hui, Qiu Tian, Yang Shi-Han, Tian Fang-Qiong, Wu Hui
机构信息
Department of Social Medicine, School of Public Health, China Medical University, Shenyang, People's Republic of China.
出版信息
Cancer Manag Res. 2020 Feb 7;12:905-912. doi: 10.2147/CMAR.S239975. eCollection 2020.
PURPOSE
We aim to test whether resilience mediates the association of fear of progression (FoP) with quality of life (QoL) among ovarian cancer patients in China.
METHODS
We collected 230 questionnaires from the First Affiliated Hospital of China Medical University in Liaoning Province, and 209 completed the questionnaire survey. The survey instrument consisted of four questionnaires: a sociodemographic and clinical characteristics questionnaire, the Functional Assessment of Cancer Therapy general instrument, the Fear of Progression Questionnaire-Short Form and the Connor-Davidson Resilience Scale. Hierarchical regression analysis was used to examine the relationship among FoP, resilience, and QoL, including physical well-being, social well-being, emotional well-being, and functional well-being. We used asymptotic and resampling strategies to examine the indirect effect of resilience.
RESULTS
FoP was negatively associated with resilience (=-0.543, <0.01) and QoL (physical well-being: =-0.537, <0.01; social well-being: =-0.426, <0.01; emotional well-being: =-0.487, <0.01; functional well-being: =-0.529, <0.01). Resilience was positively related with QoL (physical well-being: =0.449, <0.01; social well-being: =0.548, <0.01; emotional well-being: =0.430, <0.01; functional well-being: =0.655, <0.01). Resilience partly mediated the association between FoP and physical well-being (a×b=-0.05, BCa 95% CI: -0.09, -0.02), social well-being (a×b=-0.21, BCa 95% CI: -0.29, -0.14), emotional well-being (a×b=-0.05, BCa 95% CI: -0.08, -0.02), and functional well-being (a×b=-0.24, BCa 95% CI: -0.32, -0.17). The proportion of the mediating effect accounted for by resilience were 22.57%, 57.22%, 26.02%, 53.42% for physical well-being, social well-being, emotional well-being and functional well-being, respectively.
CONCLUSION
The study showed that resilience could mediate the association between fear of progression and quality of life. It suggests that resilience might provide a potential target for intervention in quality of life with ovarian cancer.
目的
我们旨在测试在中国卵巢癌患者中，心理韧性是否介导了疾病进展恐惧（FoP）与生活质量（QoL）之间的关联。
方法
我们从辽宁省中国医科大学附属第一医院收集了230份问卷，其中209份完成了问卷调查。调查工具包括四份问卷：一份社会人口学和临床特征问卷、癌症治疗功能评估通用量表、疾病进展恐惧问卷简表以及康纳-戴维森心理韧性量表。采用分层回归分析来检验FoP、心理韧性和QoL之间的关系，QoL包括身体健康、社会健康、情绪健康和功能健康。我们使用渐近和重抽样策略来检验心理韧性的间接效应。
结果
FoP与心理韧性呈负相关（=-0.543，<0.01），与QoL也呈负相关（身体健康：=-0.537，<0.01；社会健康：=-0.426，<0.01；情绪健康：=-0.487，<0.01；功能健康：=-0.529，<0.01）。心理韧性与QoL呈正相关（身体健康：=0.449，<0.01；社会健康：=0.548，<0.01；情绪健康：=0.430，<0.01；功能健康：=0.655，<0.01）。心理韧性部分介导了FoP与身体健康（a×b=-0.05，BCa 95% CI：-0.09，-0.02）、社会健康（a×b=-0.21，BCa 95% CI：-0.29，-0.14）、情绪健康（a×b=-0.05，BCa 95% CI：-0.08，-0.02）和功能健康（a×b=-0.24，BCa 95% CI：-0.32，-0.17）之间的关联。心理韧性在身体健康、社会健康、情绪健康和功能健康方面所介导效应的比例分别为２２.５７％、５７.２２％、２６.０２％、５３.４２％。
结论
该研究表明，心理韧性可以介导疾病进展恐惧与生活质量之间的关联。这表明心理韧性可能为改善卵巢癌患者的生活质量提供一个潜在的干预靶点。
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