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玻璃体内注射雷珠单抗(Lucentis)治疗放射性视网膜病变

Treatment of Radiation Retinopathy with Intravitreal Injection of Ranibizumab (Lucentis).

作者信息

Horowitz Soraya Alessandra, Damasceno Nadyr P, Damasceno Eduardo F

机构信息

Department of Ophthalmology, Hospital Naval Marcilio Dias, Rio de Janeiro, Brazil.

Department of Ophthalmology, Universidade Federal Fluminense, Niteroi, Brazil.

出版信息

Int Med Case Rep J. 2020 Feb 11;13:27-32. doi: 10.2147/IMCRJ.S191654. eCollection 2020.

Abstract

To report a treatment of radiation retinopathy in a patient exposed to ionizing radiation for a period of 2 years. A 26-year-old female patient with no comorbidities diagnosed with myelodysplasia confirmed by bone marrow biopsy. She presented a complaint of bilateral progressive visual acuity reduction. At the ophthalmologic examination, she presented alterations suggestive of radiation retinopathy as well as macular thickness to optical coherence tomography (OCT) of over 500 µm. The patient underwent intravitreal injection (0.05 mL) of ranibizumab (Lucentis) monthly in both eyes and follow-up through visual acuity and OCT examination. She presented reduction of macular edema as well as a slight improvement of visual acuity. In this case, the treatment of radiation retinopathy with intravitreal injection of ranibizumab (Lucentis) was relatively useful, with a slight improvement of visual acuity, due to the regression of macular edema, not being curative.

摘要

报告一例接受电离辐射2年的患者的放射性视网膜病变治疗情况。一名26岁无合并症的女性患者,经骨髓活检确诊为骨髓发育异常。她主诉双眼视力进行性下降。眼科检查时,她表现出提示放射性视网膜病变的改变,光学相干断层扫描(OCT)显示黄斑厚度超过500µm。该患者双眼每月接受一次雷珠单抗(Lucentis)玻璃体内注射(0.05mL),并通过视力和OCT检查进行随访。她的黄斑水肿减轻,视力略有改善。在这种情况下,玻璃体内注射雷珠单抗(Lucentis)治疗放射性视网膜病变相对有效,由于黄斑水肿消退,视力略有改善,但并非治愈性的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7d/7023963/2bd42003d6cb/IMCRJ-13-27-g0001.jpg

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