性别和年龄对中国城市人群幽门螺杆菌与大肠腺瘤性息肉相关性的影响：一项单中心研究
Effect of Gender and Age on the Correlation between Helicobacter pylori and Colorectal Adenomatous Polyps in a Chinese Urban Population: A Single Center Study.
作者信息
Zhao Xia-Xia, Liu Ming-Hao, Wang Rui-Ling, Tian Tian
机构信息
Postgraduate Training Base of Jinzhou Medical University, The PLA Rocket Force Characteristic Medical Center, Digestive Internal Medicine, Beijing, China.
The PLA Rocket Force Characteristic Medical Center, Digestive Internal Medicine, Beijing, China.
出版信息
Gastroenterol Res Pract. 2020 Feb 10;2020:8596038. doi: 10.1155/2020/8596038. eCollection 2020.
OBJECTIVES
To investigate whether Helicobacter pylori (H. pylori) infection increases the risk of colorectal adenomatous polyp (CAP) in the context of age and gender.
METHODS
A total of 563 study subjects (male/female, 368/195) from Beijing, China, with higher nursing level who underwent colonoscopy were retrospectively collected. H. pylori and CAP were detected by carbon-13 urea breath test and colorectal colonoscopy. The correlations between the number, size, distribution, and pathological grade of CAP and H. pylori infection were analyzed. The population was further stratified by age and gender in order to examine the risk of H. pylori and CAP in the context of these variables. The influence of H. pylori on the risk of CAP was assessed by logistic regression model.
RESULTS
315 participants were diagnosed with CAP, and 207 participants were classified as healthy controls. The prevalence of H. pylori in the CAP group was significantly higher than that in the healthy control group (119/315, 37.8% versus 44/207, 21.3%) ( < 0.001). The proportion of H. pylori positive plus CAP in participants <50 years old was significantly higher than that in participants >50 years old (87/250; 34.8% versus 32/65; 49.2%) ( < 0.001). The proportion of H. pylori positive plus CAP in participants <50 years old was significantly higher than that in participants >50 years old (87/250; 34.8% versus 32/65; 49.2%) ( < 0.001). The proportion of H. pylori positive plus CAP in participants <50 years old was significantly higher than that in participants >50 years old (87/250; 34.8% versus 32/65; 49.2%) ( < 0.001). The proportion of H. pylori positive plus CAP in participants <50 years old was significantly higher than that in participants >50 years old (87/250; 34.8% versus 32/65; 49.2%) (.
CONCLUSIONS
H. pylori is a major risk factor for CAP. Further studies are needed to assess the effects of H. pylori treatment or persistent infection on the occurrence or recurrence of CAP.
目的
探讨幽门螺杆菌（H. pylori）感染在年龄和性别背景下是否会增加结直肠腺瘤性息肉（CAP）的风险。
方法
回顾性收集了来自中国北京的563名接受结肠镜检查且护理水平较高的研究对象（男/女，368/195）。通过碳-13尿素呼气试验和结直肠结肠镜检查检测H. pylori和CAP。分析了CAP的数量、大小、分布和病理分级与H. pylori感染之间的相关性。为了研究在这些变量背景下H. pylori和CAP的风险，将人群进一步按年龄和性别分层。通过逻辑回归模型评估H. pylori对CAP风险的影响。
结果
315名参与者被诊断为CAP，207名参与者被归类为健康对照。CAP组中H. pylori的患病率显著高于健康对照组（119/315，37.8%对44/207，21.3%）（<0.001）。<50岁参与者中H. pylori阳性加CAP的比例显著高于>50岁参与者（87/250；34.8%对32/65；49.2%）（<0.001）。<50岁参与者中H. pylori阳性加CAP的比例显著高于>50岁参与者（87/250；34.8%对32/65；49.2%）（<0.001）。<50岁参与者中H. pylori阳性加CAP的比例显著高于>50岁参与者（87/250；34.8%对32/65；49.2%）（<0.001）。<50岁参与者中H. pylori阳性加CAP的比例显著高于>50岁参与者（87/250；34.8%对32/65；49.2%）（。
结论
H. pylori是CAP的主要危险因素。需要进一步研究来评估H. pylori治疗或持续感染对CAP发生或复发的影响。
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