Department of General Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, 410008, Changsha, Hunan, P R China.
BMC Infect Dis. 2023 Nov 14;23(1):794. doi: 10.1186/s12879-023-08791-y.
To investigate the correlation between colorectal polyps (CRP) and Helicobacter pylori (H. pylori) infection, and the correlation between CRP and the expression of phosphorylated ribosomal protein S6 kinase (p-S6K1). Besides, its related influencing factors were determined in the present study.
A total of 191 subjects who underwent colonoscopy in our hospital from January 2020 to February 2022 were selected for this study. Among them, 141 patients were diagnosed with CRP, and the other 50 subjects were no significant colorectal abnormalities. 141 CRP patients were divided into H. pylori-positive group (n = 89) and H. pylori-negative group (n = 52) according to the results of the H. pylori test. The expression of p-S6K1 in CRP tissue was detected. The relationship between the p-S6K1 expression and the clinicopathological characteristics of CRP patients was analyzed. The logistic analysis of factors influencing the occurrence of CRP was performed.
There were significant differences in pathological type, site of disease, the number and size of polyps between the H. pylori negative group and the H. pylori positive group (P < 0.001, P = 0.037, P = 0.042 and P = 0.039). The percentage of the p-S6K1 positive expression in polyp tissues was higher than that in normal tissue and parapolyp tissues (P < 0.001). The p-S6K1 negative group showed significant difference in the number and pathological type of polyps and the presence or absence of a pedicle as compared with the p-S6K1 positive group (P = 0.006, P < 0.001 and P = 0.012). Logistic multifactor analysis showed that BMI, H. pylori infection, smoking history, ApoB, Lp(a) and the p-S6K1 positive expression were all risk factors for the development of CRP (P = 0.025, P = 0.020, P = 0.010, P = 0.005, P = 0.043 and P < 0.001).
H. pylori infection was closely related to the pathological type, location, and the number and size of CRP. p-S6K1 was highly expressed in CRP, and was positively related to the number, the pathological type and pedicle of polyps. H. pylori infection and the positive p-S6K1 expression were independent risk factors for CRP. By exploring the association between H. pylori infection as well as p-S6K1 and CRP, it is hoped that it will help to formulate a more rigorous colorectal cancer screening program for H. pylori-positive individuals, and at the same time find a new direction for the prevention of CRP and colorectal cancer, and provide some help for future research.
探讨结直肠息肉（CRP）与幽门螺杆菌（H. pylori）感染的相关性，以及 CRP 与磷酸化核糖体 S6 激酶 1（p-S6K1）表达的相关性。此外，本研究还确定了其相关影响因素。
选取 2020 年 1 月至 2022 年 2 月在我院接受结肠镜检查的 191 例患者进行本研究。其中，141 例患者被诊断为 CRP，另外 50 例患者无明显结直肠异常。根据 H. pylori 检测结果，将 141 例 CRP 患者分为 H. pylori 阳性组（n=89）和 H. pylori 阴性组（n=52）。检测 CRP 组织中 p-S6K1 的表达情况。分析 p-S6K1 表达与 CRP 患者临床病理特征的关系。对影响 CRP 发生的因素进行 logistic 分析。
H. pylori 阴性组与 H. pylori 阳性组在病理类型、病变部位、息肉数量和大小方面存在显著差异（P<0.001、P=0.037、P=0.042 和 P=0.039）。息肉组织中 p-S6K1 阳性表达率高于正常组织和息肉旁组织（P<0.001）。与 p-S6K1 阳性组相比，p-S6K1 阴性组在息肉数量、病理类型、有无蒂方面存在显著差异（P=0.006、P<0.001 和 P=0.012）。多因素 logistic 分析显示，BMI、H. pylori 感染、吸烟史、ApoB、Lp（a）和 p-S6K1 阳性表达均为 CRP 发生的危险因素（P=0.025、P=0.020、P=0.010、P=0.005、P=0.043 和 P<0.001）。
H. pylori 感染与 CRP 的病理类型、部位以及息肉数量和大小密切相关。p-S6K1 在 CRP 中高表达，与息肉的数量、病理类型和蒂有关。H. pylori 感染和 p-S6K1 阳性表达是 CRP 的独立危险因素。通过探讨 H. pylori 感染以及 p-S6K1 与 CRP 之间的关系，希望能为制定更严格的 H. pylori 阳性个体结直肠癌筛查方案提供帮助，同时为 CRP 和结直肠癌的防治找到新的方向，为今后的研究提供一定的帮助。
