Sun Xiurong, Su Fangming, Chen Xuelin, Peng Qihui, Luo Xiaomin, Hao Xinghai
Department of Obstetrics and Gynecology, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China.
Department of Ultrasonography, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China.
Exp Ther Med. 2020 Mar;19(3):1955-1960. doi: 10.3892/etm.2019.8405. Epub 2019 Dec 31.
The current study investigated whether placentation and systemic inflammation are associated with pregnancy-induced hypertension (PIH) or pre-eclampsia (PE), and evaluated some measurable indexes for assessment of maternal factors contributing to high-risk pregnancy. Photoplethysmographic reflection index (PPG RI), uterine artery (UtA) pulsatile index (PI) and reflection index (RI), as well as maternal serum placental growth factor (PlGF) and soluble endoglin (sEng) were measured in pregnant women with singleton pregnancy at the gestational age of 22 to 23 weeks. Study subjects were women with normal pregnancy (NP, n=24), PIH (n=14) and PE (n=16). It was found that individuals in the PIH group exhibited higher UtA RI and UtA PI values, as well as PPG RI values compared with individuals in the NP group. Individuals in the PE group had the highest UtA RI, UtA PI and PPG RI values among these 3 groups. UtA and PPG results were significantly different in PIH and PE groups compared with the NP group. Significant differences were found in both PlGF and sEng levels between PIH and PE groups. A strong inverse across-subject correlation was found between PlGF and sEng levels. A weak inverse correlation was found between PlGF and UtA RI, and PlGF and UtA PI. A moderate inverse correlation was found between PlGF and PPG RI. A moderate positive correlation was found between either sEng and UtA RI or sEng and UtA PI. A very strong positive correlation was found between sEng and PPG RI. Taken together, the current results indicated that maternal effects related to cardiovascular adaptation to placentation and systemic inflammation exhibited significant differences between NP and PIH or PE groups. Therefore, assessment of UtA and PPG could be used for identifying high-risk pregnancy.
本研究调查了胎盘形成和全身炎症是否与妊娠高血压（PIH）或子痫前期（PE）相关，并评估了一些可测量指标以评估导致高危妊娠的母体因素。在孕22至23周的单胎妊娠孕妇中测量了光电容积脉搏波反射指数（PPG RI）、子宫动脉（UtA）搏动指数（PI）和反射指数（RI），以及母体血清胎盘生长因子（PlGF）和可溶性内皮糖蛋白（sEng）。研究对象为正常妊娠（NP，n = 24）、PIH（n = 14）和PE（n = 16）的女性。结果发现，与NP组个体相比，PIH组个体的UtA RI和UtA PI值以及PPG RI值更高。PE组个体在这三组中UtA RI、UtA PI和PPG RI值最高。与NP组相比，PIH组和PE组的UtA和PPG结果存在显著差异。PIH组和PE组之间的PlGF和sEng水平均存在显著差异。发现PlGF和sEng水平之间存在很强的受试者间负相关。发现PlGF与UtA RI、PlGF与UtA PI之间存在弱负相关。发现PlGF与PPG RI之间存在中度负相关。发现sEng与UtA RI或sEng与UtA PI之间存在中度正相关。发现sEng与PPG RI之间存在非常强的正相关。综上所述，目前的结果表明，与胎盘形成和全身炎症的心血管适应相关的母体效应在NP组与PIH组或PE组之间存在显著差异。因此，评估UtA和PPG可用于识别高危妊娠。
