Tan Roger Salvacion
Department of Chemistry, College of Science, De La Salle University, 2401 Taft Avenue, Manila 0922 Philippines.
Department of Chemistry, College of Science and Mathematics, Mindanao State University-Iligan Institute of Technology, A. Bonifacio Avenue, Tibanga, Iligan City 9200 Philippines.
Asian J Pharm Sci. 2018 May;13(3):197-211. doi: 10.1016/j.ajps.2017.12.002. Epub 2017 Dec 8.
Difference in sub-cellular trafficking of glycosylated and naked peptides, between normal and lung cancer cells, was established. Normal lung tissue discriminately sorted glycosylated from non-glycosylated peptides by allowing golgi localization of the glycosylated peptides while restricting golgi entry of the naked peptides. This mechanism was surprisingly not observed in its cancer cell counterpart. Lung cancer cells tend to allow unrestricted localization of both glycosylated and naked peptides in the golgi apparatus. This newly discovered difference in sub-cellular trafficking between normal and lung cancer cells could potentially be used as an effective strategy in targeted intracellular delivery, especially targeting golgi-resident enzymes for possible treatment of diseases associated with glycans and glycoproteins, such as, congenital disease of glycosylation (CDG). This very important detail in intracellular trafficking inside normal and cancer cells is an indispensable part in nanoparticle-based intracellular drug delivery.
正常细胞与肺癌细胞之间糖基化肽和裸肽亚细胞转运的差异已得到证实。正常肺组织通过使糖基化肽定位于高尔基体，同时限制裸肽进入高尔基体，从而有区别地分选糖基化肽和非糖基化肽。令人惊讶的是，在其癌细胞对应物中未观察到这种机制。肺癌细胞倾向于使糖基化肽和裸肽在高尔基体中不受限制地定位。正常细胞与肺癌细胞之间新发现的亚细胞转运差异可能潜在地用作靶向细胞内递送的有效策略，特别是针对高尔基体驻留酶，用于可能治疗与聚糖和糖蛋白相关的疾病，如糖基化先天性疾病（CDG）。正常细胞和癌细胞内细胞内转运的这一非常重要的细节是基于纳米颗粒的细胞内药物递送中不可或缺的一部分。
