Namviriyachote Nantaporn, Lipipun Vimolmas, Akkhawattanangkul Yada, Charoonrut Phingphol, Ritthidej Garnpimol C
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Faculty of Veterinary Science, Mahidol University, Nakhon Pathom 73170, Thailand.
Asian J Pharm Sci. 2019 Jan;14(1):63-77. doi: 10.1016/j.ajps.2018.09.001. Epub 2018 Oct 15.
Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents, silver and asiaticoside (AS) as an antimicrobial agent and an herbal wound healing agent, respectively. The foam was instantly formed by interaction of polyols and diisocyanate. Hydroxypropyl methylcellulose, chitosan and sodium alginate were individually mixed with the main polyols, polypropylene glycol, in the formulation while the active components were impregnated into the obtained foam dressing sheets. Although the type and amount of the natural polyols slightly affected the pore size, water sorption-desorption profile and compression strength of the obtained foam sheets, a prominent effect was found in the release of both active components. Among natural polyols formulations, foam sheets with alginate showed the highest silver and AS release. Non-cytotoxicity of these foam sheets to human fibroblast cells was confirmed. Antimicrobial testing on four bacteria strains showed that 1 mg/cm silver in formulations with 6% of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other formulations. In pig study, the foam dressing with 6% alginate, 1 mg/cm silver and 5% AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic reactions. In conclusion, this innovative foam dressing had potential to be a good candidate for wound treatment.
为改善泡沫特性以及两种活性剂（分别作为抗菌剂的银和作为草药伤口愈合剂的积雪草苷）的释放，用天然多元醇配制了用于皮肤伤口的聚氨酯泡沫敷料。多元醇与二异氰酸酯相互作用可立即形成泡沫。羟丙基甲基纤维素、壳聚糖和海藻酸钠分别与配方中的主要多元醇聚丙二醇混合，同时将活性成分浸渍到所得的泡沫敷料片中。尽管天然多元醇的类型和用量对所得泡沫片的孔径、水吸附 - 解吸曲线和抗压强度有轻微影响，但在两种活性成分的释放方面发现了显著效果。在天然多元醇配方中，含海藻酸盐的泡沫片银和积雪草苷的释放量最高。证实了这些泡沫片对人成纤维细胞无细胞毒性。对四种细菌菌株的抗菌测试表明，含6%天然多元醇和不含天然多元醇的配方中，1mg/cm的银具有足够的银释放量，其抑菌圈与其他配方相当且明显更大。在猪的研究中，含6%海藻酸盐、1mg/cm银和5%积雪草苷的泡沫敷料在伤口闭合百分比和皮肤伤口组织学参数方面均可改善伤口愈合，且无任何皮肤反应。总之，这种创新的泡沫敷料有潜力成为伤口治疗的良好候选产品。
