Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330 Thailand.
Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700 Thailand.
Int J Biol Macromol. 2020 Jan 15;143:510-520. doi: 10.1016/j.ijbiomac.2019.10.166. Epub 2019 Nov 25.
Polyurethane combined (PUC) foam dressings with various biomacromolecules were fabricated with the adsorption of asiaticoside and silver nanoparticles for traumatic wound treatment. Biomacromolecules had varying effects on physicochemical and mechanical properties of PU foam. With 2% incorporation, starches, high molecular weight chitosan and gelatin provided stiffer and more porous foams while carboxymethylcellulose had the highest compression strength but the lowest water vapor transmission. High water absorption was from foams with carboxymethylcellulose, alginate, hydroxypropyl methylcellulose and low molecular weight chitosan. Increasing the concentrations up to 12% had more prominent effect. However, powdery surface was noticed with poorer tensile properties that 6% incorporation was selected. FTIR spectra and DSC thermograms suggested interaction of PU formulation with biomacromolecules. EDS analysis confirmed existence of active compounds while acceptable stability was from sterilized PUC foam with alginate. On healthy volunteers, this selected foam dressing caused no skin irritation and retained moisture comparable to commercial product. In patients with traumatic dermal wounds, healing improvement with shorter wound closure time, higher reepithelialization and less pain score were from the selected foam dressing compared to standard gauze soaked with chlorhexidine. This PU-alginate combined foam dressing adsorbed with asiaticoside and silver nanoparticles proved advantages for traumatic dermal wound management.
聚氨酯复合（PUC）泡沫敷料与各种生物大分子通过吸附积雪草苷和银纳米粒子被制备用于创伤性伤口治疗。生物大分子对 PU 泡沫的物理化学和机械性能有不同的影响。在 2%的添加量下，淀粉、高分子量壳聚糖和明胶提供了更硬且更多孔的泡沫，而羧甲基纤维素则具有最高的压缩强度，但水蒸气透过率最低。羧甲基纤维素、海藻酸盐、羟丙基甲基纤维素和低分子量壳聚糖的泡沫具有较高的吸水性。增加浓度至 12%时效果更为显著。然而，添加量为 6%时，由于粉末状表面和较差的拉伸性能而被选中。FTIR 光谱和 DSC 热图表明了 PU 配方与生物大分子的相互作用。EDS 分析证实了活性化合物的存在，而经过消毒的含海藻酸盐的 PUC 泡沫具有良好的稳定性。在健康志愿者中，与市售产品相比，这种选定的泡沫敷料不会引起皮肤刺激，并且保持水分的能力相当。在创伤性皮肤伤口患者中，与氯己定浸泡的标准纱布相比，选定的泡沫敷料可缩短伤口闭合时间、提高上皮化程度并减轻疼痛评分，从而改善伤口愈合。这种吸附了积雪草苷和银纳米粒子的聚氨酯-海藻酸盐复合泡沫敷料在创伤性皮肤伤口管理方面表现出了优势。
