Ishikawa M, Takayanagi G, Sasaki K
Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Jpn J Pharmacol. 1988 Oct;48(2):283-6. doi: 10.1254/jjp.48.283.
The effect of buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, on the selenium induced-lethality was examined in mice. A single injection of BSO (500 mg/kg, i.p.) markedly decreased the concentration of GSH in the liver after 5 hr. The acute lethality induced by selenium was greatly increased in BSO-treated mice. In contrast, the selenium induced-lethality decreased by pre- and post-treatments of cysteine (100 mg/kg, i.p.) in mice.
在小鼠中研究了谷胱甘肽（GSH）生物合成抑制剂丁硫氨酸亚砜胺（BSO）对硒诱导致死率的影响。单次注射BSO（500mg/kg，腹腔注射）5小时后显著降低了肝脏中GSH的浓度。在接受BSO治疗的小鼠中，硒诱导的急性致死率大大增加。相反，小鼠经半胱氨酸（100mg/kg，腹腔注射）预处理和后处理后，硒诱导的致死率降低。
