改变大麻行业临床研究设计的基调。
Changing the Tone of Clinical Study Design in the Cannabis Industry.
作者信息
Antony Joseph M, McDonald Alison C, Noorbakhsh Farshid, Guthrie Najla, Evans Mal
机构信息
KGK Science London, London Canada.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Transl Neurosci. 2020 Feb 13;11:4-9. doi: 10.1515/tnsci-2020-0002. eCollection 2020.
Cannabis (also known as marijuana) is the most frequently used psychoactive substance globally. Cannabis exerts therapeutic functions for many indications and has vast potential as a health and wellness product. Advances in our understanding of the composition and pharmacological properties of cannabis have revealed interactions between cannabis, an individuals' circadian rhythms and and their endocannabinoid signaling. Exogenously administered cannabinoids can bidirectionally entrain central and peripheral clocks that comprise circadian rhythms, and malfunctions in the endocannabinoid system are reported to impact neurological processes. Therefore, it is necessary to account for the circadian rhythm when designing clinical trials examining the pharmacological properties of cannabis-based products for health and wellness to limit its potential confounding impact on results. Consideration of the entrainment capabilities of the endocannabinoid system is warranted when designing clinical trials.
大麻（也称为 marijuana）是全球最常使用的精神活性物质。大麻对多种适应症具有治疗作用，作为一种健康产品具有巨大潜力。我们对大麻成分和药理特性的理解取得了进展，揭示了大麻、个体昼夜节律与其内源性大麻素信号之间的相互作用。外源性给予的大麻素可双向调节构成昼夜节律的中枢和外周生物钟，据报道内源性大麻素系统功能失调会影响神经过程。因此，在设计用于健康的基于大麻产品药理特性的临床试验时，有必要考虑昼夜节律，以限制其对结果可能产生的混杂影响。在设计临床试验时，有必要考虑内源性大麻素系统的调节能力。
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