Department of Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA.
Laboratorio de Biologia, Escuela Preparatoria Regional de Autlán, Universidad de Guadalajara, Jalisco, México.
Eur J Clin Invest. 2018 May;48(5):e12920. doi: 10.1111/eci.12920. Epub 2018 Apr 2.
A generally undesired effect of cannabis smoking is a reversible disruption of short-term memory induced by delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, this paradigm has been recently challenged by a group of scientists who have shown that THC is also able to improve neurological function in old animals when chronically administered at low concentrations. Moreover, recent studies demonstrated that THC paradoxically promotes hippocampal neurogenesis, prevents neurodegenerative processes occurring in animal models of Alzheimer's disease, protects from inflammation-induced cognitive damage and restores memory and cognitive function in old mice. With the aim to reconcile these seemingly contradictory facts, this work will show that such paradox can be explained within the framework of hormesis, defined as a biphasic dose-response.
大麻吸烟的一个普遍不受欢迎的影响是大麻的主要精神活性成分 delta-9-四氢大麻酚（THC）引起的短期记忆可逆中断。然而，最近一组科学家对这一模式提出了挑战，他们表明，当 THC 以低浓度长期给予时，也能够改善老年动物的神经功能。此外，最近的研究表明，THC 反常地促进海马神经发生，防止阿尔茨海默病动物模型中发生的神经退行性过程，防止炎症引起的认知损伤，并恢复老年小鼠的记忆和认知功能。为了调和这些看似矛盾的事实，这项工作将表明，这种悖论可以在双相剂量反应定义的应激反应框架内得到解释。
