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当卒中并非只是卒中:伴脑室炎和血管炎的脑膜炎:一例报告

When a Stroke is not Just a Stroke: Meningitis with Ventriculitis and Vasculitis: A Case Report.

作者信息

Ribeiro Barbara, Bishop Peter, Jalili Sima

机构信息

Intensive Care Unit, Colchester General Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester United Kingdom.

Microbiology Department, Colchester General Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester United Kingdom.

出版信息

J Crit Care Med (Targu Mures). 2020 Jan 31;6(1):65-70. doi: 10.2478/jccm-2020-0002. eCollection 2020 Jan.

Abstract

INTRODUCTION

Community-acquired ventriculitis is considered a rare condition. Central nervous system (CNS) infection due to gram-negative bacilli is usually associated with previous neurosurgical interventions. The recent publication of cases of meningitis and ventriculitis suggests its prevalence may be underestimated by the literature.

CASE PRESENTATION

A case of community-acquired CNS infection on a 58 year old patient presenting with altered consciousness but without neck stiffness, nor significant past medical history is reported. Imaging and lumbar puncture findings suggested a complex case of meningitis with associated ventriculitis and vasculitis. was later identified in cultures. Subsequent multi-organ support in Intensive Care was required. The patient was treated with a prolonged course of intravenous antimicrobials guided by microbiology, resulting in some neurological recovery. The main challenges encountered in the management of the patient were the lack of clear recommendations on the duration of treatment and the potential development of multi-resistant organisms.

CONCLUSION

Bacterial central nervous system infections can have an atypical presentation, and an increasing number of cases of community-acquired ventriculitis have been reported. Early consideration should be given to use magnetic resonance imaging to help guide treatment. A long course of antibiotics is often required for these patients; however, the optimal duration for antimicrobial treatment is not well defined.

摘要

引言

社区获得性脑室炎被认为是一种罕见疾病。革兰氏阴性杆菌引起的中枢神经系统(CNS)感染通常与先前的神经外科手术干预有关。近期关于脑膜炎和脑室炎病例的报道表明,其患病率可能被文献低估。

病例报告

报告了一例58岁社区获得性CNS感染患者,该患者意识改变,但无颈部强直,既往病史也不显著。影像学和腰椎穿刺结果提示为复杂的脑膜炎病例,伴有脑室炎和血管炎。培养结果后来鉴定出了[病原体名称未给出]。随后在重症监护室需要进行多器官支持。患者接受了以微生物学为指导的延长疗程静脉抗菌药物治疗,神经功能有所恢复。该患者治疗中遇到的主要挑战是治疗持续时间缺乏明确建议以及多重耐药菌的潜在出现。

结论

细菌性中枢神经系统感染可能有非典型表现,并且已报道的社区获得性脑室炎病例数量不断增加。应尽早考虑使用磁共振成像来帮助指导治疗。这些患者通常需要长时间的抗生素治疗;然而,抗菌治疗的最佳持续时间尚未明确界定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa6b/7029403/8971601ef9af/jccm-06-065-g001.jpg

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