National Health and Medical Research Council Centre of Excellence in Severe Asthma, Newcastle, Australia.
Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, Australia.
Intern Med J. 2021 Feb;51(2):169-180. doi: 10.1111/imj.14806.
Severe asthma imposes a significant burden on individuals, families and the healthcare system. Treatment is complex, due to disease heterogeneity, comorbidities and complexity in care pathways. New approaches and treatments improve health outcomes for people with severe asthma. However, emerging multidimensional and targeted treatment strategies require a reorganisation of asthma care. Consensus is required on how reorganisation should occur and what areas require further research. The Centre of Excellence in Severe Asthma convened three forums between 2015 and 2018, hosting experts from Australia, New Zealand and the UK. The forums were complemented by a survey of clinicians involved in the management of people with severe asthma. We sought to: (i) identify areas of consensus among experts; (ii) define activities and resources required for the implementation of findings into practice; and (iii) identify specific priority areas for future research. Discussions identified areas of unmet need including assessment and diagnosis of severe asthma, models of care and treatment pathways, add-on treatment approaches and patient perspectives. We recommend development of education and training activities, clinical resources and standards of care documents, increased stakeholder engagement and public awareness campaigns and improved access to infrastructure and funding. Further, we propose specific future research to inform clinical decision-making and develop novel therapies. A concerted effort is required from all stakeholders (including patients, healthcare professionals and organisations and government) to integrate new evidence-based practices into clinical care and to advance research to resolve questions relevant to improving outcomes for people with severe asthma.
严重哮喘给个人、家庭和医疗保健系统带来了巨大负担。由于疾病异质性、合并症和护理途径的复杂性,治疗非常复杂。新的方法和治疗方法改善了严重哮喘患者的健康结果。然而,新兴的多维和靶向治疗策略需要重新组织哮喘护理。需要就如何进行重组以及哪些领域需要进一步研究达成共识。严重哮喘卓越中心在 2015 年至 2018 年期间举办了三次论坛,邀请了来自澳大利亚、新西兰和英国的专家参加。这些论坛还补充了一项针对严重哮喘患者管理的临床医生调查。我们试图:(i)确定专家之间的共识领域;(ii)确定将研究结果付诸实践所需的活动和资源;(iii)确定未来研究的具体优先领域。讨论确定了一些未满足的需求领域,包括严重哮喘的评估和诊断、护理模式和治疗途径、附加治疗方法和患者观点。我们建议制定教育和培训活动、临床资源和护理标准文件、增加利益相关者的参与和公众意识运动,以及改善基础设施和资金的获取。此外,我们提出了具体的未来研究,以为临床决策提供信息并开发新的治疗方法。所有利益相关者(包括患者、医疗保健专业人员和组织以及政府)都需要共同努力,将新的基于证据的实践整合到临床护理中,并推进研究,以解决与改善严重哮喘患者结局相关的问题。