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[采用股外侧肌肌瓣的切除关节成形术治疗髋关节假体关节感染复发患者]

[Resection Arthroplasty Using a Vastus Lateralis Muscle Flap in the treatment of patients with recurrent form of the hip prosthetic joint infection].

作者信息

Bozhkova S A, Liventsov V N, Kochish A Yu, Artyukh V A, Razorenov V L

机构信息

Vreden Russian Research Institute of Traumatology and Orthopedics, Saint Petersburg, Russia.

出版信息

Khirurgiia (Mosk). 2020(2):32-38. doi: 10.17116/hirurgia202002132.

Abstract

OBJECTIVE

To evaluate the efficacy of chronic recurrent hip periprosthetic joint infection (PJI) eradication after resection arthroplasty with non-free transplantation of vastus lateralis muscle flap of the thigh.

MATERIAL AND METHODS

There were 38 patients with chronic recurrent hip PJI who underwent resection arthroplasty with non-free transplantation of vastus lateralis muscle flap of the thigh in 2005-2016. The groups were compiled considering the absence or presence of recurrent infection in early postoperative period. Infection duration, number of operations, incidence of recurrent PJI, type of pathogen, laboratory parameters, bone defect size and presence of PJI remission within at least 2 years were investigated.

RESULTS

Uneventful early postoperative period after resection arthroplasty with non-free transplantation of vastus lateralis muscle flap was noted in 81.6% of cases (n=31, group 1). Postoperative wound revision was required in 18.4% of cases (n=7, group 2). Stable remission of infection within 2-8 years (Me - 4 years) was achieved in 36 (94.7%) patients. Relative risk of recurrent PJI increased by more than 4 times (RR 4,364, 95% CI 0,581-32,787) in cases of polymicrobial infection involving Gram-negative bacteria and decreased in cases of monomicrobial infection (RR 0,256, 95% CI 0,034-1,916). Significantly longer duration of surgery and more pronounced laboratory changes were revealed in group 2.

CONCLUSION

High efficacy of resection arthroplasty with non-free transplantation of vastus lateralis muscle flap of the thigh was established in patients with chronic recurrent hip PJI. This procedure might be considered as a stage treatment with the possibility for revision arthroplasty in case of failed initial debridement surgery due to PJI pathogens that are difficult for eradication.

摘要

目的

评估采用带蒂股外侧肌肌瓣移植的关节切除成形术治疗慢性复发性髋关节假体周围感染(PJI)的疗效。

材料与方法

2005年至2016年间,38例慢性复发性髋关节PJI患者接受了带蒂股外侧肌肌瓣移植的关节切除成形术。根据术后早期有无复发性感染对患者进行分组。研究了感染持续时间、手术次数、复发性PJI的发生率、病原体类型、实验室参数、骨缺损大小以及至少2年内PJI缓解情况。

结果

81.6%的病例(n = 31,第1组)在带蒂股外侧肌肌瓣移植的关节切除成形术后早期恢复顺利。18.4%的病例(n = 7,第2组)需要进行术后伤口修复。36例(94.7%)患者在2至8年(中位数 - 4年)内实现了感染的稳定缓解。涉及革兰氏阴性菌的多微生物感染病例中,复发性PJI的相对风险增加了4倍多(RR 4.364,95% CI 0.581 - 32,),而单微生物感染病例中相对风险降低(RR 0.256,95% CI 0.034 - 1.916)。第2组手术时间明显更长,实验室变化更明显。

结论

对于慢性复发性髋关节PJI患者,采用带蒂股外侧肌肌瓣移植的关节切除成形术具有较高疗效。如果由于难以根除的PJI病原体导致初次清创手术失败,该手术可被视为一种分期治疗方法,且有可能进行翻修关节成形术。

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