IRCSS SDN, Via Gianturco, 80131, Naples, Italy.
Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatologic Sciences, School of Medicine, "Federico II" University of Naples, 80131 Naples, Italy.
Cell Calcium. 2020 May;87:102170. doi: 10.1016/j.ceca.2020.102170. Epub 2020 Feb 7.
The Na/Ca exchanger plays a relevant role in several neurological disorders, thus the pharmacological modulation of its isoforms might represent a promising strategy to ameliorate the course of some neurological pathologies including stroke, neonatal hypoxia, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer Disease (AD), and spinal muscular atrophy (SMA). This review will summarize heterocyclic, peptidergic, genetic and epigenetic compounds activating or inhibiting the expression/activity of each NCX isoform. In addition, we will focus our attention on the development of new strategies aimed to ameliorate the pathophysiological conditions in which NCX isoform changes are found.
钠/钙交换器在几种神经紊乱疾病中起着重要作用，因此，对其异构体进行药理学调节可能是改善某些神经病理学过程的一种有前途的策略，包括中风、新生儿缺氧、多发性硬化症 (MS)、肌萎缩侧索硬化症 (ALS)、阿尔茨海默病 (AD) 和脊髓性肌萎缩症 (SMA)。这篇综述将总结具有激活或抑制每个 NCX 异构体表达/活性的杂环、肽类、遗传和表观遗传化合物。此外，我们将把注意力集中在开发新策略上，以改善发现 NCX 异构体变化的病理生理条件。
