Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Int J Mol Sci. 2020 Feb 25;21(5):1562. doi: 10.3390/ijms21051562.
Casein kinase I (CK1), a ubiquitous serine/threonine (Ser/Thr) protein kinase in eukaryotes, plays pivotal roles in a wide spectrum of cellular functions including metabolism, cell cycle progression, developmental control and stress responses. Plant CK1 evolves a lineage expansion, resulting in a unique branch of members exclusive to the kingdom. Among them, Arabidopsis Mut9p-LIKE KINASEs (MLKs) target diverse substrates including histones and the key regulatory proteins involving in physiological processes of light signaling, circadian rhythms, phytohormone and plant defense. Deregulation of the kinase activity by mutating the enzyme or the phosphorylation sites of substrates causes developmental disorders and susceptibility to adverse environmental conditions. MLKs have evolved as a general kinase that modifies transcription factors or primary regulatory proteins in a dynamic way. Here, we summarize the current knowledge of the roles of and orthologs in several commercially important crops.
酪蛋白激酶 I（CK1）是真核生物中普遍存在的丝氨酸/苏氨酸（Ser/Thr）蛋白激酶，在包括代谢、细胞周期进程、发育控制和应激反应在内的广泛细胞功能中发挥关键作用。植物 CK1 经历了谱系扩张，导致了一个独特的成员分支，专属于该领域。其中，拟南芥 Mut9p 样激酶（MLKs）靶向包括组蛋白和关键调节蛋白在内的多种底物，这些蛋白参与光信号、昼夜节律、植物激素和植物防御等生理过程。通过突变酶或底物的磷酸化位点来调节激酶活性会导致发育障碍和对不利环境条件的敏感性。MLKs 已经进化为一种通用激酶，以动态方式修饰转录因子或主要调节蛋白。在这里，我们总结了几个商业上重要作物中 和 同源物的作用的最新知识。
