新替扎美辛和 1.10-菲咯啉金属配合物的生物学和光谱学研究。

Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes.

机构信息

School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.

Department of Chemistry, Faculty of Science, Zagazig University, 44519 Zagazig, Egypt.

出版信息

Molecules. 2020 Feb 25;25(5):1027. doi: 10.3390/molecules25051027.

In the present work, tenoxicam (HTen) reacted with Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) ions in the presence of 1.10-phenthroline (Phen), forming new mixed ligand metal complexes. The properties of the formed complexes were depicted by elemental analyses, infrared, electronic spectra, proton nuclear magnetic resonance (H NMR), mass spectrometry, thermogravimetric (TGA) and differential thermogravimetric (DTG) analysis, molar conductance and magnetic moment. IR spectra demonstrated that HTen acted as a neutral bidentate ligand, coordinated to the metal ions via the pyridine-N and carbonyl group of the amide moiety, and Phen through the nitrogen atoms. Kinetic thermodynamics parameters activation energy (E*), enthalpy of activation (ΔH*), entropy of activation (ΔS*), Gibbs, free energy (ΔG*) associated to the complexes have been evaluated. Antibacterial screening of the compounds was carried out in vitro against , and . Antifungal activity was performed in vitro against , and . The possible phytotoxic effect of the studied compounds was also investigated on (tomatoes) and (garden cress) seeds. The anticancer activity was screened against cell cultures of HCT-116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and MCF-7 (human breast adenocarcinoma).

在本工作中，在 1,10-菲啰啉（Phen）的存在下，tenoxicam（HTen）与 Mn(II)、Co(II)、Ni(II)、Cu(II)和 Zn(II)离子反应，形成新的混合配体金属配合物。通过元素分析、红外、电子光谱、质子核磁共振（H NMR）、质谱、热重（TGA）和差示热重（DTG）分析、摩尔电导率和磁矩描绘了形成的配合物的性质。IR 光谱表明 HTen 作为中性双齿配体，通过吡啶-N 和酰胺部分的羰基与金属离子配位，通过氮原子与 Phen 配位。评估了与配合物相关的动力学热力学参数活化能（E*）、活化焓（ΔH*）、活化熵（ΔS*）、吉布斯自由能（ΔG*）。在体外对、、进行了化合物的抗菌筛选。在体外对、、进行了抗真菌活性测试。还研究了所研究化合物对（番茄）和（花园荠）种子的潜在植物毒性效应。对 HCT-116（人结肠直肠癌细胞）、HepG2（人肝癌细胞）和 MCF-7（人乳腺癌腺癌细胞）的细胞培养进行了抗癌活性筛选。