ICH Study Center, Hamburg, Germany.
Department of Medicine II, University of Schleswig-Holstein, Campus Kiel, Germany.
AIDS Care. 2021 Apr;33(4):453-461. doi: 10.1080/09540121.2020.1733466. Epub 2020 Feb 27.
In people living with HIV (PLWH), a decade-long antiretroviral therapy (ART) poses new challenges regarding physical and mental health. The aim of this cross-sectional study is to investigate the health-related quality of life (HRQOL) in adult HIV-infected patients with viral suppression and an ART exposure for at least 5 years in three German HIV centers. Patients were evaluated by the ACTG Augmented Symptoms Distress Module (ASDM) and the SF-12 Health Survey. Among 894 patients, symptom-related distress was highly prevalent. The most common symptoms were fatigue, insomnia, sadness and depression, sexual dysfunction, and changes in body appearance. In the multivariate analysis, ART duration, age and depression were significantly associated with a higher overall symptom summary score. Self-reported mean SF-12 scores were lower for mental health and younger patients compared to the standard random sample of a healthy German population. Depression and occupational status were significantly related to a lower physical component summary score, by contrast older age was associated with higher scores in the mental component summary, implying more favorable mental health status. In this large group of PLWH, the degree of symptom-related distress was high. Mental and physical health should be considered an integral part of ongoing HIV care.
在艾滋病毒感染者（PLWH）中，长达十年的抗逆转录病毒疗法（ART）对身心健康带来了新的挑战。本横断面研究旨在探讨德国三个 HIV 中心中至少接受 5 年抗病毒治疗且病毒抑制的成年 HIV 感染患者的健康相关生活质量（HRQOL）。通过 ACTG 增强症状困扰模块（ASDM）和 SF-12 健康调查对患者进行评估。在 894 名患者中，与症状相关的困扰高度普遍。最常见的症状是疲劳、失眠、悲伤和抑郁、性功能障碍和身体外观改变。在多变量分析中，ART 持续时间、年龄和抑郁与更高的整体症状总结评分显著相关。与健康德国人群的标准随机样本相比，自我报告的 SF-12 平均分数在心理健康和年轻患者中较低。抑郁和职业状况与较低的身体成分总分显著相关，而年龄较大与心理成分总分较高相关，这意味着心理健康状况更为有利。在这个庞大的 PLWH 群体中，与症状相关的困扰程度很高。心理健康和身体健康应被视为持续 HIV 护理的一个组成部分。
