Neuropsychiatric Institute, Prince of Wales Hospital, Australia.
University of New South Wales, Australia.
Australas Psychiatry. 2020 Apr;28(2):199-201. doi: 10.1177/1039856220905299. Epub 2020 Feb 27.
The current guidelines recommend screening all patients with first episode psychosis (FEP) for anti-NMDA receptor encephalitis. This paper explores the pitfalls of this strategy.
Screening for anti-NMDA receptor encephalitis in patients with FEP when the pre-test probability based on the clinical presentation is low creates a risk of false positive results. Testing based on clinical suspicion would be preferable.
目前的指南建议对所有首发精神病（FEP）患者进行抗 N-甲基-D-天冬氨酸受体脑炎（抗 NMDA 受体脑炎）筛查。本文探讨了该策略的缺陷。
当基于临床表现的先验概率较低时，对 FEP 患者进行抗 NMDA 受体脑炎筛查会导致假阳性结果的风险。基于临床怀疑进行检测会更好。
