Mayo Clinic Rochester, Division of General Internal Medicine, Rochester, MN.
Mayo Clinic Rochester, Division of General Internal Medicine, Rochester, MN.
Mayo Clin Proc. 2020 May;95(5):1064-1079. doi: 10.1016/j.mayocp.2019.08.013. Epub 2020 Feb 24.
Major adverse cardiac events are common causes of perioperative mortality and major morbidity. Preventing these complications requires thorough preoperative risk assessment and postoperative monitoring of at-risk patients. Major guidelines recommend assessment based on a validated risk calculator that incorporates patient- and procedure-specific factors. American and European guidelines define when stress testing is needed on the basis of functional capacity assessment. Favoring cost-effectiveness, Canadian guidelines instead recommend obtaining brain natriuretic peptide or N-terminal prohormone of brain natriuretic peptide levels to guide postoperative screening for myocardial injury or infarction. When conditions such as acute coronary syndrome, severe pulmonary hypertension, and decompensated heart failure are identified, nonemergent surgery should be postponed until the condition is appropriately managed. There is an evolving role of biomarkers and myocardial injury after noncardiac surgery to enhance risk stratification, but the effect of interventions guided by these strategies is unclear.
主要心脏不良事件是围手术期死亡和主要并发症的常见原因。预防这些并发症需要彻底的术前风险评估和对高危患者的术后监测。主要指南建议基于包含患者和手术特定因素的经过验证的风险计算器进行评估。美国和欧洲的指南根据功能能力评估定义何时需要应激测试。为了考虑成本效益,加拿大指南建议获得脑利钠肽或脑利钠肽前体水平,以指导术后筛查心肌损伤或梗死。当存在急性冠状动脉综合征、严重肺动脉高压和心力衰竭失代偿等情况时,应推迟非紧急手术,直到病情得到适当治疗。非心脏手术后生物标志物和心肌损伤的作用正在不断发展,以增强风险分层,但这些策略指导的干预效果尚不清楚。