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Wip1 regulates hematopoietic stem cell development in the mouse embryo.

作者信息

He Wenyan, Wang Xiaobo, Ni Yanli, Li Zongcheng, Liu Wei, Chang Zhilin, Li Haowen, Ju Zhenyu, Li Zhuan

机构信息

China National Clinical Res Center for Neurological Diseases, Beijing Tiantan Hospital, China.

Laboratory of Oncology, Fifth Medical Center, General Hospital of PLA, Beijing, China.

出版信息

Haematologica. 2021 Feb 1;106(2):580-584. doi: 10.3324/haematol.2019.235481.

DOI:10.3324/haematol.2019.235481
PMID:32107340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7849554/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/7849554/a71bac9c3216/106580.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/7849554/fe2f313953c0/106580.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/7849554/86ed5fe5ed50/106580.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/7849554/a71bac9c3216/106580.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/7849554/fe2f313953c0/106580.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/7849554/86ed5fe5ed50/106580.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/7849554/a71bac9c3216/106580.fig3.jpg

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本文引用的文献

1
Blood Development: Hematopoietic Stem Cell Dependence and Independence.血液发育:造血干细胞的依赖性和独立性。
Cell Stem Cell. 2018 May 3;22(5):639-651. doi: 10.1016/j.stem.2018.04.015.
2
DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation.DNA损伤诱导的磷酸酶Wip1在造血、免疫系统和炎症调节中的作用
Cell Death Discov. 2017 Apr 3;3:17018. doi: 10.1038/cddiscovery.2017.18. eCollection 2017.
3
Subregional localization and characterization of Ly6aGFP-expressing hematopoietic cells in the mouse embryonic head.
小鼠胚胎头部中表达Ly6aGFP的造血细胞的亚区域定位与特征分析
Dev Biol. 2016 Aug 1;416(1):34-41. doi: 10.1016/j.ydbio.2016.05.031. Epub 2016 May 25.
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Tracing haematopoietic stem cell formation at single-cell resolution.单细胞分辨率追踪造血干细胞的形成。
Nature. 2016 May 26;533(7604):487-92. doi: 10.1038/nature17997. Epub 2016 May 18.
5
Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.Wip1 缺失通过 p53 和 mTORC1 通路损害造血干细胞功能。
Nat Commun. 2015 Apr 16;6:6808. doi: 10.1038/ncomms7808.
6
Mouse embryonic head as a site for hematopoietic stem cell development.小鼠胚胎头部作为造血干细胞发育的部位。
Cell Stem Cell. 2012 Nov 2;11(5):663-75. doi: 10.1016/j.stem.2012.07.004.
7
Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos.整体小鼠胚胎血管中造血集落的三维绘图。
Development. 2010 Nov;137(21):3651-61. doi: 10.1242/dev.051094. Epub 2010 Sep 28.
8
Haematopoietic stem cells derive directly from aortic endothelium during development.造血干细胞在发育过程中直接来源于主动脉内皮。
Nature. 2010 Mar 4;464(7285):108-11. doi: 10.1038/nature08738. Epub 2010 Feb 14.
9
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium.从鼠主动脉内皮细胞中出现的造血细胞的体内成像。
Nature. 2010 Mar 4;464(7285):116-20. doi: 10.1038/nature08764. Epub 2010 Feb 14.
10
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter.Runx1对于内皮细胞向造血细胞的转变是必需的,但在此之后则不是。
Nature. 2009 Feb 12;457(7231):887-91. doi: 10.1038/nature07619. Epub 2009 Jan 7.