Service de chirurgie digestive, endocrinienne et générale, CHU de Limoges, Avenue Martin Luther King, Limoges Cedex, 87042, France.
Department of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Rue Gabrielle Perret-Gentil 4, 1205, Geneva, Switzerland.
Sci Rep. 2020 Feb 27;10(1):3643. doi: 10.1038/s41598-020-60481-w.
Hartmann's reversal procedures are often fraught with complications or failure to recover. This being a fact, it is often difficult to select patients with the optimal indications for a reversal. The post-recovery morbidity and mortality rates in the literature are heterogeneous between 0.8 and 44%. The identification of predictive risk factors of failure of such interventions would therefore be very useful to help the practitioner in his approach. Given these elements, it was important to us to analyze the practice of two French university hospitals in order to highlight such risk factors and to allow surgeons to select the best therapeutic strategy. We performed a bicentric observational retrospective study between 2010 and 2015 that studied the characteristics of patients who had undergone Hartmann surgery and were subsequently reestablished. The aim of the study was to identify factors influencing morbidity and postoperative mortality of Hartmann's reversal. Primary outcome was complications within the first 90 postoperative days. 240 patients were studied of which 60.4% were men. The mean age was 69.48 years. The median time to reversal was 8 months. 79.17% of patients were operated as emergency cases where the indication was a diverticular complication (39.17%). Seventy patients (29.2%) underwent a reversal and approximately 43% of these had complications within the first 90 postoperative days. The mean age of these seventy patients was 61.3 years old and 65.7% were males. None of them benefited from a reversal in the first three months. We identified some risk factors for morbidity such as pre-operative low albuminemia (p = 0.005) and moderate renal impairment (p = 0.019). However, chronic corticosteroid use (p = 0.004), moderate renal insufficiency (p = 0.014) and coronary artery disease (p = 0.014) seem to favour the development of anastomotic fistula, which is itself, a risk factor for mortality (p = 0.007). Our study highlights an important rate of complications including significant anastomotic fistula after Hartmann's reversal. Precarious nutritional status and cardiovascular comorbidities should clearly lead us to reconsider the surgical indication for continuity restoration.
哈特曼(Hartmann)手术的逆转过程常常充满并发症或无法恢复。事实上,很难选择具有最佳逆转适应证的患者。文献中报道的术后发病率和死亡率在 0.8%至 44%之间存在异质性。因此,识别此类干预措施失败的预测风险因素对于帮助医生进行治疗非常有用。考虑到这些因素,我们对法国两家大学医院的实践进行了分析,以突出这些风险因素,并使外科医生能够选择最佳的治疗策略。我们进行了一项 2010 年至 2015 年的回顾性观察性研究,研究了接受哈特曼手术并随后重建的患者的特征。研究目的是确定影响哈特曼手术逆转的发病率和术后死亡率的因素。主要结果是术后 90 天内的并发症。共研究了 240 名患者,其中 60.4%为男性。平均年龄为 69.48 岁。逆转的中位时间为 8 个月。79.17%的患者为急症手术,适应证为憩室并发症(39.17%)。70 例(29.2%)患者进行了逆转,其中约 43%在术后 90 天内出现并发症。这 70 名患者的平均年龄为 61.3 岁,其中 65.7%为男性。他们中没有人在头三个月接受过逆转治疗。我们确定了一些发病率的风险因素,如术前低白蛋白血症(p=0.005)和中度肾功能不全(p=0.019)。然而,慢性皮质类固醇的使用(p=0.004)、中度肾功能不全(p=0.014)和冠心病(p=0.014)似乎有利于吻合口瘘的发展,而吻合口瘘本身是死亡率的一个风险因素(p=0.007)。我们的研究强调了哈特曼手术逆转后存在较高的并发症发生率,包括严重的吻合口瘘。不稳定的营养状况和心血管合并症显然应促使我们重新考虑连续性恢复的手术适应证。