Department of Radiology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, PR China.
Postdoctoral Research Station of Special Medicine, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, PR China.
Future Med Chem. 2020 May;12(9):835-852. doi: 10.4155/fmc-2019-0330. Epub 2020 Feb 28.
Drug-induced liver injury (DILI) has been a long-standing concern of modern medicine, and the single most frequent reason for drug nonapprovals and postapproval restrictions or withdrawals. Chemical probes for early diagnosis of DILI has triggered a tremendous interest in the field of molecular imaging. In this review, we make a brief summary of the recently developed chemical probes and their applications in DILI imaging with special attention to the design of chemical probes, mechanism of their actions and their performances in DILI imaging.
药物性肝损伤（DILI）一直是现代医学关注的焦点，也是药物批准后限制或撤市的最常见原因。用于早期诊断 DILI 的化学探针在分子成像领域引起了极大的兴趣。在这篇综述中，我们简要总结了最近开发的化学探针及其在 DILI 成像中的应用，特别关注化学探针的设计、作用机制及其在 DILI 成像中的性能。
