Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853, United States.
Chem Rev. 2020 Jun 24;120(12):5252-5307. doi: 10.1021/acs.chemrev.9b00629. Epub 2020 Feb 28.
The metallobiochemistry underlying the formation of the inorganic N-N-bond-containing molecules nitrous oxide (NO), dinitrogen (N), and hydrazine (NH) is essential to the lifestyles of diverse organisms. Similar reactions hold promise as means to use N-based fuels as alternative carbon-free energy sources. This review discusses research efforts to understand the mechanisms underlying biological N-N bond formation in primary metabolism and how the associated reactions are tied to energy transduction and organismal survival. These efforts comprise studies of both natural and engineered metalloenzymes as well as synthetic model complexes.
无机含氮-氮键分子一氧化二氮 (NO)、氮气 (N) 和联氨 (NH) 的形成所涉及的金属生物化学对各种生物的生活方式至关重要。类似的反应有望成为使用基于氮的燃料作为替代无碳能源的手段。本综述讨论了理解初级代谢中生物氮-氮键形成的机制的研究进展，以及相关反应如何与能量转导和生物体生存联系起来。这些努力包括对天然和工程金属酶以及合成模型配合物的研究。
