Rekhi Bharat
Department of Surgical Pathology, Tata Memorial Centre, HBNI University, Mumbai, Maharashtra, India.
Indian J Pathol Microbiol. 2020 Feb;63(Supplement):S70-S80. doi: 10.4103/IJPM.IJPM_832_19.
Over the years, immunohistochemistry has emerged as a powerful tool for a more precise diagnosis of certain tumors in gynecologic oncopathology and resolving certain diagnostic dilemmas with significant treatment implications. Certain specific immunohistochemical (IHC) markers have been useful in the more correct identification of rare tumors, characterized by specific molecular signatures. Immunohistochemistry has also been useful in the identification of underlying genetic events, characterizing various tumors, as well as precancerous lesions. This review will focus upon the judicious application of various IHC antibody markers in gynec oncopathology, including authors' experience during "sign-outs" and especially during interaction with other oncology colleagues within the institutional disease management group. The updated references were retrieved from PubMed.
多年来，免疫组织化学已成为一种强大的工具，用于更精确地诊断妇科肿瘤病理学中的某些肿瘤，并解决某些具有重大治疗意义的诊断难题。某些特定的免疫组织化学（IHC）标志物有助于更准确地识别具有特定分子特征的罕见肿瘤。免疫组织化学在识别潜在的基因事件、表征各种肿瘤以及癌前病变方面也很有用。本综述将重点关注各种IHC抗体标志物在妇科肿瘤病理学中的合理应用，包括作者在“签出”过程中的经验，特别是在与机构疾病管理组内的其他肿瘤学同事互动期间的经验。更新的参考文献从PubMed检索。
