Strutz J, Zöllner C
Univ.-HNO-Klinik Freiburg/Br.
Laryngol Rhinol Otol (Stuttg). 1988 Jul;67(7):340-2.
An anatomical study was conducted to determine the effects of 10% lidocain base (dissolved in DMSO) on the structure of the tympanic membrane. Survival times ranged from 1 day to 3 months. Membranes were embedded in plastic and cut in semithin sections. Within 1 and 3 days mild swelling of the epithelium was seen; 1 month after treatment the connective tissue layers of the lamina propria were severely hyperplastic. 2 months after lidocain-Base application additional collagen fibres, loosely packed and less regularly, appeared in the submucosal connective tissue layer. However, normal appearance of the drums was noticeable after 3 months survival.
进行了一项解剖学研究，以确定10%利多卡因碱（溶于二甲基亚砜）对鼓膜结构的影响。存活时间从1天到3个月不等。将鼓膜嵌入塑料中并切成半薄切片。在1天和3天内可见上皮轻度肿胀；治疗1个月后，固有层的结缔组织层严重增生。应用利多卡因碱2个月后，黏膜下结缔组织层出现额外的胶原纤维，排列松散且不太规则。然而，存活3个月后鼓膜外观恢复正常。
