Vrabec J T, Schwaber M K, Davidson J M, Clymer M A
Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tenn.
Laryngoscope. 1994 Sep;104(9):1059-64. doi: 10.1288/00005537-199409000-00002.
Basic fibroblast growth factor (bFGF) has been shown to enhance speed of wound repair at a number of anatomic sites. This study presents an evaluation of bFGF in a model of acute tympanic membrane (TM) perforation in order to assess rate of healing as well as structural and functional outcome. Perforations were created in the tympanic membranes of rats, then allowed to heal in the presence of topically applied bFGF with the opposite ear serving as a control. The growth factor was applied in repeated doses beginning 2 days after creation of the TM defect. The treated ears healed faster by an average of 4.0 days. The healed tympanic membranes were assessed using tympanometry and light microscopy. Structurally and functionally, the healed tympanic membranes were similar to the controls. The observed results indicate that bFGF promotes accelerated healing and restoration of normal architecture in acute TM defects.
碱性成纤维细胞生长因子（bFGF）已被证明可提高多个解剖部位的伤口修复速度。本研究对急性鼓膜（TM）穿孔模型中的bFGF进行评估，以评估愈合速度以及结构和功能结果。在大鼠鼓膜上制造穿孔，然后在局部应用bFGF的情况下使其愈合，对侧耳作为对照。从TM缺损形成后第2天开始重复给药生长因子。治疗组耳朵平均愈合时间快4.0天。使用鼓室导抗图和光学显微镜对愈合的鼓膜进行评估。在结构和功能上，愈合的鼓膜与对照组相似。观察结果表明，bFGF可促进急性TM缺损的加速愈合和正常结构的恢复。
