Wilson Rogers Luke P, Rennoldson Mike
Author Affiliation: Department of Psychology, Nottingham Trent University, Nottingham, UK.
Cancer Nurs. 2020 May/Jun;43(3):E121-E131. doi: 10.1097/NCC.0000000000000786.
Fatigue, pain, and psychological distress have been found to be among the most significant quality of life concerns for patients with multiple myeloma. Strong links between these variables have been found in other cancer populations.
The aim of this study was to systematically review the research literature on the associations between psychosocial factors and pain and/or fatigue in patients with multiple myeloma.
INTERVENTIONS/METHODS: The review followed PRISMA guidelines. A systematic search of 3 databases was conducted. Included studies were appraised for risk of bias. Data were extracted and combined in a narrative synthesis.
The review identified 11 studies for inclusion, reporting data from a total of 2432 participants. It found consistent evidence of a medium-sized relationship between both global distress and depression on the one hand and pain and fatigue on the other. The included studies were highly varied in the psychosocial factors they investigated.
There is good evidence that pain and fatigue are related to global distress and depression in patients with multiple myeloma. The evidence on relationships with other psychosocial factors is inconclusive. Research investigating the role of more specific psychosocial processes is called for.
Assessment of pain and fatigue in patients with multiple myeloma should routinely include screening for psychological distress. Interventions for psychological distress may be considered as adjuvant intervention strategies for pain and fatigue in patients with multiple myeloma.
疲劳、疼痛和心理困扰已被发现是多发性骨髓瘤患者生活质量方面最重要的问题。在其他癌症人群中已发现这些变量之间存在紧密联系。
本研究的目的是系统回顾关于多发性骨髓瘤患者心理社会因素与疼痛和/或疲劳之间关联的研究文献。
干预措施/方法：该综述遵循PRISMA指南。对3个数据库进行了系统检索。对纳入的研究进行偏倚风险评估。提取数据并进行叙述性综合分析。
该综述确定了11项纳入研究，报告了总共2432名参与者的数据。研究发现，一方面整体困扰和抑郁与另一方面疼痛和疲劳之间存在中等程度关系的一致证据。纳入研究在其调查的心理社会因素方面差异很大。
有充分证据表明，多发性骨髓瘤患者的疼痛和疲劳与整体困扰和抑郁有关。与其他心理社会因素关系的证据尚无定论。需要开展研究以调查更具体心理社会过程的作用。
对多发性骨髓瘤患者的疼痛和疲劳评估应常规包括心理困扰筛查。对于心理困扰的干预可被视为多发性骨髓瘤患者疼痛和疲劳的辅助干预策略。
