Department of Physiology, Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, An-Najah National University, New Campus, Building: 19, Office: 1340, P.O. Box 7, Nablus, Palestine.
Clinical Research Center, An-Najah National University Hospital, Nablus, 44839, Palestine.
Ann Hematol. 2023 Dec;102(12):3543-3554. doi: 10.1007/s00277-023-05482-1. Epub 2023 Oct 6.
Little studies were conducted to assess the health -related quality of life (HR-QoL) of patients with multiple myeloma (MM) in developing and resource-limited countries. This study assessed the HR-QoL of patients with MM who received treatment in the Palestinian healthcare system as an example of healthcare systems in developing and resource-limited countries. Predictors of deteriorated HR-QoL of the affected patients were also identified. In this cross-sectional study, the tool was a questionnaire that collected the demographic and disease variables of the patients. The questionnaire also contained the EORTC QLQ-MY24 items. The questionnaire was piloted to ensure readability, clarity, and comprehensibility. Additionally, the test-retest reliability and internal consistency were also assessed. In this study, 45.5% of patients with MM who were treated in the Palestinian healthcare system returned usable questionnaires. The mean age of the patients was 60.7 ± 7.5 years and the mean time elapsed since diagnosis was 2.6 ± 1.7 years. Of the patients, 54.3%, 47.8%, 46.7%, 66.3%, 46.7%, and 46.7% reported frequent bone pain, pain that increased with activity, back pain, feeling ill, lost hair, and feeling restless or agitated, respectively. Higher disease symptom scores were predicted by low self-rated satisfaction with the ability to do daily life activities and low self-rated satisfaction with overall health. The side effects of treatment scores were predicted by longer time elapsed since diagnosis and low self-rated satisfaction with overall health. Future perspective scores were predicted by low self-rated satisfaction with overall health. On the other hand, social support scores were predicted by having a university education and not receiving radiotherapy. Patients with MM who were treated in the Palestinian healthcare system reported a heavy burden of disease symptoms, treatment adverse effects, and dissatisfaction with the information they received about their disease. The findings reported in this study are informative to hemato-oncologists and other healthcare providers who care for patients with MM in Palestine and other developing and resource-limited countries. Policymakers might use the findings reported in this study to design interventions to improve the HR-QoL of the patients.
很少有研究评估发展中国家和资源有限国家的多发性骨髓瘤 (MM) 患者的健康相关生活质量 (HR-QoL)。本研究以巴勒斯坦医疗保健系统中接受治疗的 MM 患者为例，评估了发展中国家和资源有限国家医疗保健系统中 MM 患者的 HR-QoL。还确定了影响患者 HR-QoL 恶化的预测因素。在这项横断面研究中，工具是一份问卷，收集了患者的人口统计学和疾病变量。问卷还包含了 EORTC QLQ-MY24 项目。对问卷进行了预测试，以确保可读性、清晰度和可理解性。此外，还评估了测试-重测信度和内部一致性。在这项研究中，45.5%在巴勒斯坦医疗保健系统中接受治疗的 MM 患者返回了可用的问卷。患者的平均年龄为 60.7 ± 7.5 岁，自诊断以来的平均时间为 2.6 ± 1.7 年。54.3%、47.8%、46.7%、66.3%、46.7%和 46.7%的患者分别报告频繁骨痛、活动时疼痛增加、背痛、感觉不适、脱发和感到不安或激动。较低的自我报告对日常生活活动能力的满意度和对整体健康状况的自我报告满意度预测更高的疾病症状评分。治疗副作用评分由自诊断以来的时间更长和对整体健康状况的自我报告满意度较低预测。未来展望评分由对整体健康状况的自我报告满意度较低预测。另一方面，社会支持评分由接受大学教育和未接受放疗预测。在巴勒斯坦医疗保健系统中接受治疗的 MM 患者报告疾病症状、治疗不良反应和对疾病信息的不满负担沉重。本研究报告的结果为在巴勒斯坦和其他发展中国家和资源有限国家照顾 MM 患者的血液肿瘤学家和其他医疗保健提供者提供了信息。政策制定者可能会利用本研究报告的结果来设计干预措施，以提高患者的 HR-QoL。
