College of ocean science and engineering, Shanghai Maritime University, Shanghai, China.
Phytomedicine. 2020 Mar;68:153190. doi: 10.1016/j.phymed.2020.153190. Epub 2020 Feb 13.
A growing number of studies have been focused on the medicinal potential of natural products since 1962, while few scholars have analyzed the existing documents comprehensively.
Aiming to visualize the researches on toxicology and pharmacology of natural products (TPNP) published between 1962 and 2018, as well as to reveal their spatiotemporal patterns, a scientometric analysis with 3210 relevant documents collected from Web of Science was conducted in this study.
The most prominent contributors of TPNP research are mainly from the USA, China, Brazil, India and Germany. The knowledge domains of TPNP research focus mainly on the topics of (1) traditional Chinese medicine, (2) richardia grandiflora, (3) chemical conversion, (4) new generation, (5) modern medicine, (6) intelligent mixture, (7) hplc-based activity. Most countries have recognized the pharmaceutical potential of natural products, and have paid more attention to the pharmacological and toxicological characteristics of natural products in the past decade. Future TPNP research tends to focus more on complex analysis of mechanisms for diseases treatment, such as toxicology and pharmacology.
This research has firstly demonstrated a comprehensive knowledge map for the existing toxicological and pharmacological researches of natural products, which offered essential instructions on medical application of natural products to future research.
自 1962 年以来，越来越多的研究关注天然产物的药用潜力，而很少有学者全面分析现有的文献。
本研究旨在通过对从 Web of Science 收集的 3210 篇相关文献进行科学计量分析，可视化 1962 年至 2018 年期间天然产物毒理学和药理学（TPNP）的研究，并揭示其时空格局。
TPNP 研究的主要贡献者主要来自美国、中国、巴西、印度和德国。TPNP 研究的知识领域主要集中在以下主题：（1）中药，（2）大花紫薇，（3）化学转化，（4）新一代，（5）现代医学，（6）智能混合物，（7）基于 HPLC 的活性。大多数国家已经认识到天然产物的药用潜力，并在过去十年中更加关注天然产物的药理学和毒理学特征。未来 TPNP 研究倾向于更加关注疾病治疗机制的复杂分析，如毒理学和药理学。
本研究首次展示了天然产物毒理学和药理学现有研究的综合知识图谱，为未来天然产物的医学应用提供了重要的指导。
