扎姆扎姆水对大鼠血糖状态、血脂谱、氧化还原稳态及身体成分的影响。

Effects of Zamzam water on glycemic status, lipid profile, redox homeostasis, and body composition in rats.

作者信息

AlJuwaie Ghadeer F, Latif Rabia, AlSheikh Mona H, Al Sunni Ahmed, Chathoth Shahanas

机构信息

Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, KSA.

Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, KSA.

出版信息

J Taibah Univ Med Sci. 2020 Feb 7;15(1):14-18. doi: 10.1016/j.jtumed.2019.12.008. eCollection 2020 Feb.

DOI:10.1016/j.jtumed.2019.12.008

PMID:32110177

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7033411/

Abstract

OBJECTIVES

Previous studies have demonstrated that Zamzam water exerts beneficial effects on several ailments such as diabetes mellitus, nephrotoxicity, hepatotoxicity, and stress. The present study aimed to assess the effects of Zamzam water on glycemic status, lipid profile, redox homeostasis, and body composition in healthy rats.

METHODS

Twenty-four rats were divided into two equal groups. Rats were fed a chow diet along with either tap or Zamzam water as the only fluid source. After ten weeks, fasting blood glucose, serum insulin, insulin resistance, low density lipoproteins (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, superoxide dismutase, and lipid peroxidation were measured. Adipose pads and carcass (musculoskeletal only) were weighed and residual body weight was calculated. The groups were compared using independent sample test (unpaired).

RESULTS

The following parameters were significantly reduced in the Zamzam water group compared to the tap water group: fasting blood sugar, 96.5 vs. 147.1 mg/dl ( = 0.00); serum insulin, 0.44 vs. 1.31 μU/l ( = 0.00); and insulin resistance, 1.89 vs. 8.40 ( = 0.00). LDL cholesterol, HDL cholesterol, superoxide dismutase, lipid peroxidation, weight of the body, fat pads, and carcass, as well as residual body weight (both absolute and relative) showed no significant changes.

CONCLUSION

Zamzam water intake for ten weeks decreases fasting blood sugar, serum insulin, and insulin resistance. However, Zamzam water has no effect on lipid profile, redox homeostasis, and body composition.

摘要

目的

先前的研究表明，渗渗泉水对多种疾病具有有益作用，如糖尿病、肾毒性、肝毒性和应激反应。本研究旨在评估渗渗泉水对健康大鼠血糖状态、血脂谱、氧化还原稳态和身体组成的影响。

方法

将24只大鼠平均分为两组。大鼠食用普通饲料，分别饮用自来水或渗渗泉水作为唯一的液体来源。十周后，测量空腹血糖、血清胰岛素、胰岛素抵抗、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇、超氧化物歧化酶和脂质过氧化水平。称量脂肪垫和胴体（仅肌肉骨骼部分）的重量，并计算剩余体重。使用独立样本t检验（非配对）对两组进行比较。

结果

与自来水组相比，渗渗泉水组的以下参数显著降低：空腹血糖，96.5对147.1mg/dl（P = 0.00）；血清胰岛素，0.44对1.31μU/l（P = 0.00）；胰岛素抵抗，1.89对8.40（P = 0.00）。LDL胆固醇、HDL胆固醇、超氧化物歧化酶、脂质过氧化、体重、脂肪垫、胴体以及剩余体重（绝对和相对）均无显著变化。