Reddy K Vijayram, Shastry Shamee, Raturi Manish, Baliga B Poornima
Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, India.
Manipal Academy of Higher Education, Manipal, India.
Transfus Med Hemother. 2020 Feb;47(1):75-79. doi: 10.1159/000499768. Epub 2019 May 3.
Regular and repeat blood donations may cause reduced body iron stores (BIS), which may lead to a shrinking donor pool. Furthermore, hemoglobin (Hb) itself is quite an inadequate measure to detect iron deficiency. Hence, our primary aim was to understand the effect of repeated blood donations on BIS in regular blood donors.
We conducted a prospective study on voluntary whole-blood donors (September 2015 through August 2017). Donor demographics were noted. Donors were further divided into four groups, depending on their number of donations. Their samples were tested for Hb, red cell indices, and serum ferritin to check for reduced BIS. The data obtained were analyzed using SPSS version 20 (IBM, USA).
A total of 374 regular voluntary blood donors were included in the study. The mean serum ferritin levels in males and females were 75.4 and 36.2µg/L, respectively. There was a 45% decrement in the mean serum ferritin values in Group I (101.57 µg/L) in contrast to Group III (56.69 µg/L) ( < 0.0032). In the study, 9.8, 11.2, and 4.8% of the donors were in Stage 1, Stage 2, and Stage 3 of reduced BIS, respectively. Of the donors, 11.2% were in Stage 2 of reduced BIS. Further donations in such cases can compromise donor safety.
The present study demonstrates iron depletion in regular voluntary blood donors. In 11.2% of the donors, iron deficiency erythropoiesis was noted. A ferritin screening after the first donation followed up at the tenth donation might help detect iron-deficient individuals. Iron supplementation for all regular blood donors and female donors in particular will help prevent the shrinking donor pool due to iron deficiency.
定期且重复献血可能导致体内铁储备（BIS）减少，这可能会使献血者群体萎缩。此外，血红蛋白（Hb）本身对于检测缺铁而言是相当不充分的指标。因此，我们的主要目的是了解重复献血对定期献血者体内铁储备的影响。
我们对自愿全血献血者进行了一项前瞻性研究（2015年9月至2017年8月）。记录了献血者的人口统计学数据。根据献血次数，献血者被进一步分为四组。检测他们的样本中的血红蛋白、红细胞指数和血清铁蛋白，以检查体内铁储备是否减少。使用SPSS 20版软件（美国IBM公司）对获得的数据进行分析。
该研究共纳入374名定期自愿献血者。男性和女性的平均血清铁蛋白水平分别为75.4和36.2μg/L。与第三组（56.69μg/L）相比，第一组（101.57μg/L）的平均血清铁蛋白值下降了45%（P<0.0032）。在该研究中，分别有9.8%、11.2%和4.8%的献血者处于体内铁储备减少的第1阶段、第2阶段和第3阶段。在这些献血者中，11.2%处于体内铁储备减少的第2阶段。在这种情况下进一步献血可能会危及献血者安全。
本研究表明定期自愿献血者存在铁耗竭情况。在11.2%的献血者中，观察到缺铁性红细胞生成。首次献血后进行铁蛋白筛查，并在第10次献血时进行随访，可能有助于检测出缺铁个体。对所有定期献血者，尤其是女性献血者进行铁补充，将有助于防止因缺铁导致的献血者群体萎缩。
