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Thrombus on the inflow cannula of the HeartWare HVAD: an update.HeartWare HVAD流入插管上的血栓:最新情况
Cardiovasc Pathol. 2019 Jan-Feb;38:14-20. doi: 10.1016/j.carpath.2018.09.002. Epub 2018 Sep 15.
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Depression and anxiety in patients undergoing left ventricular assist device implantation.接受左心室辅助装置植入手术患者的抑郁和焦虑
Int J Artif Organs. 2017 Nov 1:0. doi: 10.5301/ijao.5000650.
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The Relationship of Anxiety, Depression, and Quality of Life in Adults With Left Ventricular Assist Devices.左心室辅助装置成人的焦虑、抑郁与生活质量的关系。
ASAIO J. 2018 Jul/Aug;64(4):515-520. doi: 10.1097/MAT.0000000000000681.
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Eighth annual INTERMACS report: Special focus on framing the impact of adverse events.第八年度 INTERMACS 报告:特别关注不良事件影响的构建。
J Heart Lung Transplant. 2017 Oct;36(10):1080-1086. doi: 10.1016/j.healun.2017.07.005. Epub 2017 Jul 15.
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Dying With a Left Ventricular Assist Device as Destination Therapy.以左心室辅助装置作为终末期治疗手段的临终情况。
Circ Heart Fail. 2016 Oct;9(10). doi: 10.1161/CIRCHEARTFAILURE.116.003096.
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Acquired von Willebrand syndrome associated with left ventricular assist device.与左心室辅助装置相关的获得性血管性血友病综合征
Blood. 2016 Jun 23;127(25):3133-41. doi: 10.1182/blood-2015-10-636480. Epub 2016 May 3.
7
Seventh INTERMACS annual report: 15,000 patients and counting.国际机械循环辅助装置注册研究(INTERMACS)第七年度报告:15000例患者及仍在增加。
J Heart Lung Transplant. 2015 Dec;34(12):1495-504. doi: 10.1016/j.healun.2015.10.003. Epub 2015 Oct 8.
8
Left Ventricular Assist Devices: A Rapidly Evolving Alternative to Transplant.左心室辅助装置:一种迅速发展的移植替代方法。
J Am Coll Cardiol. 2015 Jun 16;65(23):2542-55. doi: 10.1016/j.jacc.2015.04.039.
9
Sixth INTERMACS annual report: a 10,000-patient database.国际机械循环辅助装置注册研究(INTERMACS)第六年度报告:一个包含10000名患者的数据库。
J Heart Lung Transplant. 2014 Jun;33(6):555-64. doi: 10.1016/j.healun.2014.04.010. Epub 2014 Apr 21.
10
Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients.第五次 INTERMACS 年度报告:来自 6000 多名机械循环支持患者的风险因素分析。
J Heart Lung Transplant. 2013 Feb;32(2):141-56. doi: 10.1016/j.healun.2012.12.004.

14例左心室辅助装置患者死亡案例的法医学考量

Forensic Considerations in a Series of 14 Deaths of Patients with a Left Ventricular Assist Device.

作者信息

Lin Peter T, Thomas Sarah

出版信息

Acad Forensic Pathol. 2019 Sep;9(3-4):200-211. doi: 10.1177/1925362119893459. Epub 2020 Jan 31.

DOI:10.1177/1925362119893459
PMID:32110255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6997991/
Abstract

INTRODUCTION

To better understand the forensic implications of death with a left ventricular assist device (LVAD), we reviewed all deaths that were reported to a regional medical examiner jurisdiction involving patients who had an LVAD.

METHODS

Medical examiner case files between January 2012 and September 2018 were searched for "LVAD" and "left ventricular assist device" to identify deaths that were reported to the medical examiner involving a decedent who had an LVAD at the time of death.

RESULTS

During the study period, a total of 14 deaths were reported to the regional medical examiner involving decedents who had an implanted LVAD at the time of death. The average age at death was 64 years, with a range from 40 to 81 years. The underlying cardiac disease leading to LVAD implantation was ischemic heart disease (n = 9), nonischemic dilated cardiomyopathy (n = 4), and chemotherapy-related cardiotoxicity (n = 1). Of these 14 deaths, 2 deaths were due to loss of power to the LVAD, 1 death was due to traumatic subdural hemorrhage occurring in the setting of anticoagulation therapy required by LVAD implantation, and 1 death was due to femur fracture following a fall.

DISCUSSION

Medical examiners should be familiar with the potential complications of LVADs, especially those complications that may prompt consideration of non-natural manners of death. Medical examiners should also be aware of the tools and investigative strategies that may assist in the investigation of LVAD-related deaths.

摘要

引言

为了更好地理解左心室辅助装置(LVAD)相关死亡的法医学意义,我们回顾了向地区法医管辖机构报告的所有涉及使用LVAD患者的死亡案例。

方法

检索2012年1月至2018年9月期间法医的案件档案,查找“LVAD”和“左心室辅助装置”,以确定向法医报告的涉及在死亡时使用LVAD的死者的死亡案例。

结果

在研究期间,地区法医共报告了14例死亡案例,死者在死亡时植入了LVAD。平均死亡年龄为64岁,范围为40至81岁。导致植入LVAD的潜在心脏疾病为缺血性心脏病(n = 9)、非缺血性扩张型心肌病(n = 4)和化疗相关心脏毒性(n = 1)。在这14例死亡中,2例是由于LVAD断电,1例是由于在LVAD植入所需的抗凝治疗过程中发生创伤性硬膜下出血,1例是由于跌倒后股骨骨折。

讨论

法医应熟悉LVAD的潜在并发症,尤其是那些可能促使考虑非自然死亡方式的并发症。法医还应了解可能有助于调查LVAD相关死亡的工具和调查策略。