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外用西多福韦治疗免疫抑制移植患者难治性广泛性外阴高级别鳞状上皮内病变：一例报告

Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report.

作者信息

Lim Darosa, Belisle Annie, Funaro Deana

机构信息

Division of Dermatology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.

Department of Pathology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.

出版信息

SAGE Open Med Case Rep. 2020 Feb 16;8:2050313X20904542. doi: 10.1177/2050313X20904542. eCollection 2020.

DOI:10.1177/2050313X20904542
PMID:32110405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7026838/
Abstract

High-grade squamous intraepithelial lesion of the vulva is a premalignant condition which may be especially resistant to treatments among immunosuppressed patients. We present our experience with the use of topical cidofovir in a refractory case of extensive vulvar high-grade squamous intraepithelial lesion in a 37-year-old transplant patient. Eighteen cycles of cidofovir over a 2-year period led to a sustained significant improvement, mainly of the mucosal lesions and was well tolerated. To our knowledge, we have not seen this therapy described in transplant patients with extensive high-grade squamous intraepithelial lesion.

摘要

外阴高级别鳞状上皮内病变是一种癌前病变，在免疫抑制患者中可能对治疗具有特殊的抗性。我们介绍了在一名37岁移植患者的广泛外阴高级别鳞状上皮内病变难治性病例中使用局部西多福韦的经验。在2年期间进行的18个周期的西多福韦治疗带来了持续显著的改善，主要是黏膜病变方面，并且耐受性良好。据我们所知，我们尚未见到在患有广泛高级别鳞状上皮内病变的移植患者中描述过这种疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/8cda70334123/10.1177_2050313X20904542-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/c70feabbec34/10.1177_2050313X20904542-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/2d0ccd40b274/10.1177_2050313X20904542-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/5ebff7bd7659/10.1177_2050313X20904542-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/8cda70334123/10.1177_2050313X20904542-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/c70feabbec34/10.1177_2050313X20904542-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/2d0ccd40b274/10.1177_2050313X20904542-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/5ebff7bd7659/10.1177_2050313X20904542-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a91/7026838/8cda70334123/10.1177_2050313X20904542-fig4.jpg

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本文引用的文献

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Recurrence of vulval intraepithelial neoplasia following treatment with cidofovir or imiquimod: results from a multicentre, randomised, phase II trial (RT3VIN).在使用西多福韦或咪喹莫特治疗后外阴上皮内瘤变的复发：来自一项多中心、随机、II 期试验（RT3VIN）的结果。
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The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions.
2015年国际外阴阴道疾病研究学会（ISSVD）外阴鳞状上皮内病变术语
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Vulvar Intraepithelial Neoplasia (VIN) and Condylomata.外阴上皮内瘤变（VIN）与尖锐湿疣
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Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT³VIN): a multicentre, open-label, randomised, phase 2 trial.西多福韦和咪喹莫特治疗外阴上皮内瘤变（RT³VIN）的活性、安全性和可行性：一项多中心、开放性标签、随机、2 期试验。
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Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women.局部应用西多福韦治疗 HIV 阳性男性和女性肛周及外阴高级别上皮内瘤变的安全性和有效性。
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Is the incidence of invasive vulvar cancer increasing in the United States?美国外阴浸润性癌的发病率是否在上升？
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Clinical responses to Cidofovir applied topically to women with high grade vulval intraepithelial neoplasia.西多福韦局部应用于高级别外阴上皮内瘤变女性患者的临床反应。
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Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers.抗病毒药物西多福韦可恢复p53功能并增强人乳头瘤病毒相关癌症的放射敏感性。
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