Gomez Mariangela, Whitting Kerry, Naous Rana
Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA.
SAGE Open Med Case Rep. 2020 Feb 16;8:2050313X20907208. doi: 10.1177/2050313X20907208. eCollection 2020.
Metastatic carcinomas to the uterus are rare and usually originate from nearby gynecologic sites, most commonly from the ovaries. Among non-gynecologic origins, breast tumors are the most frequent primaries, predominantly the lobular carcinoma type. A 69-year-old postmenopausal woman diagnosed with lobular breast carcinoma 5 years ago, status post modified radical mastectomy, and currently on tamoxifen therapy presented with post-menopausal bleeding. Subsequent endometrial biopsy confirmed the diagnosis of metastatic lobular breast carcinoma to the endometrium. Breast carcinomas rarely metastasize to the uterus, especially lobular carcinoma type. Abnormal uterine bleeding in a patient with known history of breast carcinoma and under tamoxifen therapy should prompt a complete diagnostic workup to rule out metastatic disease.
子宫转移性癌罕见，通常起源于附近的妇科部位，最常见于卵巢。在非妇科起源中，乳腺肿瘤是最常见的原发灶，主要是小叶癌类型。一名69岁绝经后女性，5年前诊断为小叶性乳腺癌，接受改良根治性乳房切除术后，目前正在接受他莫昔芬治疗，出现绝经后出血。随后的子宫内膜活检证实为子宫内膜转移性小叶性乳腺癌。乳腺癌很少转移至子宫，尤其是小叶癌类型。已知有乳腺癌病史且正在接受他莫昔芬治疗的患者出现子宫异常出血，应进行全面的诊断性检查以排除转移性疾病。
