Rezaei Fatemeh, Fatholahi Saeedeh, Rezaei Farzad
Department of Oral Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
General Dentist, Department of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Family Med Prim Care. 2020 Jan 28;9(1):72-76. doi: 10.4103/jfmpc.jfmpc_375_19. eCollection 2020 Jan.
One of the possible ways of changing human health might be through the oral mucosa. One of tongue disorders is geographic tongue (GT), which classic manifestation is an area of erythema, with atrophy of filiform papillae of the tongue, surrounded by a serpiginous, white, hyperkeratotic border. Saliva is a rich source of antioxidant and fulfills an important role in maintaining the normal function of the oral cavity. The purpose of the present study was to investigate the status of salivary antioxidant and immunoglobulin E in patients with GT and healthy people.
In this case-control study, samples were gathered from high school students in three municipal regions of Kermanshah, Iran by using multistage random cluster sampling method. The samples included 30 patients with GT (15 men and 15 women with the mean age of 17.6 ± 0.72) and 30 healthy volunteers (15 men and 15 women with the mean age of 17.1 ± 0.61). Saliva samples were collected through standard method, and total antioxidant capacity (TAC), catalase (CAT), and salivary immunoglobulin E were measured.
In patients with GT, unstimulated salivary shows increased level of immunoglobulin compared with that of control group ( = 0.013). However, there was no significant relationship between control and GT patient groups regarding TAC of saliva ( = 0.91) and CAT ( = 0.83).
It seems that the activity of CAT enzyme and TAC of saliva does not play primary role in the pathogenesis of GT. However, the level of immunoglobulin E present in saliva can function as an indicator of increased sensitivity in GT.
改变人类健康的一种可能途径或许是通过口腔黏膜。舌部疾病之一是地图舌（GT），其典型表现是红斑区域，舌丝状乳头萎缩，周围有匐行性白色角化过度边界。唾液是抗氧化剂的丰富来源，在维持口腔正常功能中发挥重要作用。本研究的目的是调查地图舌患者和健康人群唾液抗氧化剂及免疫球蛋白E的状况。
在这项病例对照研究中，采用多阶段随机整群抽样方法，从伊朗克尔曼沙阿三个市区的高中生中采集样本。样本包括30名地图舌患者（15名男性和15名女性，平均年龄17.6±0.72岁）和30名健康志愿者（15名男性和15名女性，平均年龄17.1±0.61岁）。通过标准方法收集唾液样本，并测量总抗氧化能力（TAC）、过氧化氢酶（CAT）和唾液免疫球蛋白E。
与对照组相比，地图舌患者非刺激性唾液中的免疫球蛋白水平升高（P = 0.013）。然而，在唾液TAC（P = 0.91）和CAT（P = 0.83）方面，对照组和地图舌患者组之间没有显著关系。
唾液中CAT酶的活性和TAC似乎在地图舌的发病机制中不起主要作用。然而，唾液中存在的免疫球蛋白E水平可作为地图舌敏感性增加的指标。
