Dubicanac Marko, Joly Marine, Strüve Julia, Nolte Ingo, Mestre-Francés Nadine, Verdier Jean-Michel, Zimmermann Elke
Institute of Zoology, University of Veterinary Medicine Hannover, Bünteweg 17, Hannover, 30559, Germany.
Small Animal Clinic, University of Veterinary Medicine Hannover, Bünteweg 4, Hannover, 30559, Germany.
Vet Ophthalmol. 2018 May;21(3):319-327. doi: 10.1111/vop.12434. Epub 2016 Sep 13.
The aim of this study was to assess the practicability of common tonometers used in veterinary medicine for rapid intraocular pressure (IOP) screening, to calibrate IOP values gained by the tonometers, and to define a reference IOP value for the healthy eye in a new primate model for aging research, the gray mouse lemur.
TonoVet and the TonoPen measurements were calibrated manometrically in healthy enucleated eyes of mouse lemurs euthanized for veterinary reasons. For comparison of the practicability of both tonometers as a rapid IOP assessment tool for living mouse lemurs, the IOP of 24 eyes of 12 animals held in the hand was measured. To define a standard reference value for IOP in mouse lemurs, 258 healthy animals were measured using the TonoVet .
Intraocular pressure measurements for the TonoVet can be corrected using the formula: y = 0.981 + (1.962TonoVet value), and those for the TonoPen using that of y = 5.38 + (1.426TonoPen value). The calibrated IOP for a healthy mouse lemur eye was 20.3 ± 2.8 mmHg. The TonoVet showed advantages in practicability, for example, small corneal contact area, short and painless corneal contact, shortened total time spent on investigation, as well as the more accurate measured values. IOP measurements of healthy mouse lemur eyes were not affected by age, sex, eye side, or colony.
Tonometry using TonoVet is the more practicable assessment tool for IOP measurement of the tiny eyes of living mouse lemurs. Pathological deviations can be identified based on the described reference value.
本研究旨在评估兽医学中常用眼压计用于快速眼内压（IOP）筛查的实用性，校准眼压计获得的IOP值，并在一种用于衰老研究的新型灵长类动物模型——灰鼠狐猴中确定健康眼睛的参考IOP值。
在因兽医原因安乐死的健康灰鼠狐猴摘除眼球上，对TonoVet眼压计和TonoPen眼压计进行了压力校准测量。为比较这两种眼压计作为活体灰鼠狐猴快速IOP评估工具的实用性，测量了12只动物手持的24只眼睛的IOP。为确定灰鼠狐猴IOP的标准参考值，使用TonoVet眼压计对258只健康动物进行了测量。
TonoVet眼压计的眼压测量值可使用公式y = 0.981 + (1.962×TonoVet测量值)进行校正，TonoPen眼压计的眼压测量值可使用公式y = 5.38 + (1.426×TonoPen测量值)进行校正。健康灰鼠狐猴眼睛的校准IOP为20.3±2.8 mmHg。TonoVet眼压计在实用性方面表现出优势，例如角膜接触面积小、角膜接触时间短且无痛、缩短了总检查时间以及测量值更准确。健康灰鼠狐猴眼睛的IOP测量不受年龄、性别、眼别或群体的影响。
使用TonoVet眼压计进行眼压测量是测量活体灰鼠狐猴小眼睛IOP更实用的评估工具。可根据所述参考值识别病理偏差。
